81083-58-1

Basic information

• Product Name: diethyl N-(2,2,2-trifluoroacetyl)-L-aspartate
• CAS NO: 81083-58-1
• Molecular Weight: 257.166
• Mol File: 81083-58-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diethyl N-(2,2,2-trifluoroacetyl)-L-aspartate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N-(2,2,2-trifluoroacetyl)-L-aspartate(81083-58-1)
• EPA Substance Registry System: diethyl N-(2,2,2-trifluoroacetyl)-L-aspartate(81083-58-1)

Safety Data

• Hazardous Substances Data: 81083-58-1(Hazardous Substances Data)

Upstream product

• 6384-18-5 L-Aspartic acid dimethyl ester 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 67-56-1 methanol 
• 64881-40-9 (3S)-3-methoxycarbonyl-3-trifluoroacetylaminopropanoyl chloride 
• 32213-95-9 dimethyl L-aspartate hydrochloride 
• 407-25-0 trifluoroacetic anhydride 
• 1356449-88-1 calyxamide B 
• 1356449-87-0 calyxamide A 
• 777-33-3 N-trifluoroacetyl-L-aspartic acid anhydride 
• 88668-76-2 methyl (2S)-5-diazo-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate 

Relevant articles and documents

Two separate and distinct syntheses of stereospecifically deuteriated samples of (2S)-proline

Two distinct syntheses of samples of the amino acid l-proline which are stereospecifically deuteriated on the β-carbon atom are reported. In the first of these, the labelled diazoketones 6, prepared by a chemico-enzymatic synthesis, have been photolysed in alkaline conditions to give the corresponding labelled methyl pyroglutamates 10 via hydrolysis and intramolecular trapping of the resultant ketene intermediates 9. These were then converted into (2S,3S)-[3-2H1]- and (2S,3R)-[2,3-2H 2]-proline, 1a and 1b respectively. The second synthesis provides (2S)-[3,3-2H2]-, (2S,3S)- and (2S,3R)-[3- 2H1]-proline, 1d, 1a and 1c respectively, and has as its key step the highly stereoselective hydrolysis of the silylenol ethers 14 and 14a respectively in which deuteriation or protonation occurs from the re-face of the enol ether. The Royal Society of Chemistry 2006.

Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx

Cyclic peptides containing 5-hydroxytryptophan and thiazole moieties were isolated from the marine sponge Discodermia calyx collected near Shikine-jima Island, Japan. The structures of calyxamides A (1) and B (2), including the absolute configurations of all amino acids, were elucidated by spectroscopic analyses and degradation experiments. The structures are similar to keramamides F and G, previously isolated from Theonella sp. The analysis of the 16S rDNA sequences obtained from the metagenomic DNA of D. calyx revealed the presence of Candidatus Entotheonella sp., an unculturable δ-proteobacterium inhabiting the Theonella genus and implicated in the biosynthesis of bioactive peptides.