81123-99-1

Basic information

• Product Name: 2-Pentadecanone, 1,1,1-trifluoro-
• Synonyms: 2-Pentadecanone, 1,1,1-trifluoro-
• CAS NO: 81123-99-1
• Molecular Formula: C15H27 F3 O
• Molecular Weight: 0
• Mol File: 81123-99-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 295.3°C at 760 mmHg
• Flash Point: 194.3°C
• Appearance: /
• Density: 0.967g/cm³
• Vapor Pressure: 0.00154mmHg at 25°C
• Refractive Index: 1.411
• CAS DataBase Reference: 2-Pentadecanone, 1,1,1-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentadecanone, 1,1,1-trifluoro-(81123-99-1)
• EPA Substance Registry System: 2-Pentadecanone, 1,1,1-trifluoro-(81123-99-1)

Safety Data

• Hazardous Substances Data: 81123-99-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H27F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(19)15(16,17)18/h2-13H2,1H3

Upstream product

• 544-63-8 n-tetradecanoic acid 
• 407-25-0 trifluoroacetic anhydride 
• 112-64-1 tetradecanoyl chloride 
• 124-10-7 methyl myristoate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Relevant articles and documents

New methodology toward α,β-unsaturated carboxylic acids from saturated acids

A carefully designed three-step unsaturation of carboxylic acids is described. Briefly, carboxylic acids were converted to the trifluoromethyl ketone. Subsequent treatment with selenium dioxide followed by hydrolysis afforded α,β-unsaturated carboxylic acids. The mechanism of the reported transformation was investigated, which led us to propose a novel explanation featuring selenium dioxide assisted enolizaion of a trifluoromethyl ketone followed by β-deprotonation.

Direct preparation of trifluoromethyl ketones from carboxylic esters: Trifluoromethylation with (trifluoromethyl)trimethylsilane

Previously difficult to prepare, alipathic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacologic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane is induced by tetrabutylammonium fluoride in nonpolar, aprotic solvents and proceeds without formation of double-addition products.