811842-25-8

Basic information

• Product Name: L-4'-TETRAHYDROPYRANYLGLYCINE
• Synonyms: (S)-2-Amino-2-(tetrahydro-2H-pyran-4-yl)aceticacid;L-4'-Tetrahydropyranylglycine;REF DUPL: L-4'-Tetrahydropyranylglycine;2H-Pyran-4-acetic acid, .alpha.-aminotetrahydro-, (.alpha.S)-;(S)-a-Aminotetrahydro-2H-pyran-4-acetic acid;(S)-2-Amino-2-(tetrahydro-2H-pyran-4-yl)ethanoic acid
• CAS NO: 811842-25-8
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.184
• Mol File: 811842-25-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 316.7 °C at 760 mmHg
• Flash Point: 145.3 °C
• Appearance: /
• Density: 1.211 g/cm³
• Vapor Pressure: 8.62E-05mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: L-4'-TETRAHYDROPYRANYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: L-4'-TETRAHYDROPYRANYLGLYCINE(811842-25-8)
• EPA Substance Registry System: L-4'-TETRAHYDROPYRANYLGLYCINE(811842-25-8)

Safety Data

• Hazardous Substances Data: 811842-25-8(Hazardous Substances Data)

Usage

General Description

L-4'-Tetrahydropyranyl glycine is a chemical compound that is a derivative of glycine, a naturally occurring amino acid in the human body. The addition of a tetrahydropyranyl group to glycine provides protection for the amino acid during chemical reactions and synthesis processes. This modification allows for the selective deprotection of the glycine molecule, making it a useful building block in organic synthesis and pharmaceutical development. L-4'-Tetrahydropyranyl glycine is often used in the production of peptide and protein-based drugs, as well as in the synthesis of complex organic molecules. It is an important chemical compound in the field of medicinal and pharmaceutical chemistry, providing a valuable tool for the creation of new drugs and therapeutics.

InChI:InChI=1/C7H13NO3/c8-6(7(9)10)5-1-3-11-4-2-5/h5-6H,1-4,8H2,(H,9,10)/t6-/m0/s1

Upstream product

• 871261-02-8 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid 
• 861160-58-9 C₉H₁₄O₄ 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Downstream Products

• 1433280-55-7 [(S)-2-((2S,4S)-4-methyl-2-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid methyl ester 
• 1433280-54-6 [(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester 
• 1009120-03-9 (S)-methoxycarbonylamino(tetrahydropyran-4-yl)acetic acid 

Relevant articles and documents

SYNTHESIS METHOD FOR L-CYCLIC ALKYL AMINO ACID AND PHARMACEUTICAL COMPOSITION HAVING THEREOF

A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD+, and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is where n1≧1, m1≧0 and the M1 is H or a monovalent cation; the Structural Formula (II) is where n2≧0, m2≧0, the M2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.