81201-82-3 Usage
Description
(20S)-3-oxopregna-1,4-diene-20-carboxaldehyde is a chemical compound derived from the pregnane family, characterized by its unique 20S stereochemistry and the presence of a 3-oxo group and a 20-carboxaldehyde functional group. This steroidal compound exhibits significant potential in the pharmaceutical industry due to its structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
(20S)-3-oxopregna-1,4-diene-20-carboxaldehyde is used as a key reactant in the synthesis of novel parathiosteroids, which are therapeutic agents designed for the treatment of tumors. Its unique structural features allow for the development of new steroidal compounds with enhanced antitumor properties, offering potential benefits in cancer therapy.
In the preparation of these parathiosteroids, (20S)-3-oxopregna-1,4-diene-20-carboxaldehyde serves as a valuable intermediate, enabling the creation of diverse steroidal structures with tailored pharmacological properties. This contributes to the advancement of cancer treatment options and the ongoing search for more effective and targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 81201-82-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,0 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 81201-82:
(7*8)+(6*1)+(5*2)+(4*0)+(3*1)+(2*8)+(1*2)=93
93 % 10 = 3
So 81201-82-3 is a valid CAS Registry Number.
81201-82-3Relevant articles and documents
Lithocholic Acid Side-chain Cleavage to Produce 17-Keto or 22-Aldehyde Steroids by Pseudomonas putida strain ST-491 Grown in the Presence of an Organic Solvent, Diphenyl Ether
Suzuki, Yasumasa,Doukyu, Noriyuki,Aono, Rikizo
, p. 2182 - 2188 (1998)
We devised a method to screen for microorganisms capable of growing on bile acids in the presence of organic solvents and producing organic solvent-soluble derivatives. Pseudomonas putida biovar A strain ST-491 isolated in this study produced decarboxylated derivatives from the bile acids. Strain ST-491 grown on 0.5% lithocholic acid catabolized approximately 30% of the substrate as a carbon source, and transiently accumulated in the medium androsta-1,4-diene-3,17-dione in an amount of corresponding to 5% of the substrate added. When 20% (v/v) diphenyl ether was added to the medium, 60% of the substrate was converted to 17-keto steroids (androst-4-ene-3,17-dione-like steroid, androsta-1,4-diene-3,17-dione) or a 22-aldehyde steroid (pregna-1,4-dien-3-on-20-al). Amounts of the products were responsible for 45, 10, and 5% of the substrate, respectively. In the presence of the surfactant Triton X-100 instead of diphenyl ether, 40% of the substrate was converted exclusively to androsta-1,4-diene-3,17-dione.
