81211-89-4

Basic information

• Product Name: 1-amino-3-(dimethylamino)pyridin-1-ium 2,4,6-trimethylbenzenesulfonate
• CAS NO: 81211-89-4
• Molecular Weight: 337.443
• Mol File: 81211-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-amino-3-(dimethylamino)pyridin-1-ium 2,4,6-trimethylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-3-(dimethylamino)pyridin-1-ium 2,4,6-trimethylbenzenesulfonate(81211-89-4)
• EPA Substance Registry System: 1-amino-3-(dimethylamino)pyridin-1-ium 2,4,6-trimethylbenzenesulfonate(81211-89-4)

Safety Data

• Hazardous Substances Data: 81211-89-4(Hazardous Substances Data)

Upstream product

• 36016-39-4 N-(tert-butoxycarbonyl)-O-(mesitylsulfonyl)hydroxylamine 

Relevant articles and documents

Regioselective Synthesis of Pyrazolo[1,5- a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds was developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone, and Metochalcone, and a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies show that TEMPO serves both as a Lewis acid and as an oxidant.