81226-60-0 Usage
Description
L 741626, also known as a selective D2DR inhibitor, is a G protein-coupled receptors antagonist and inverse agonist. It has been widely used in various applications due to its unique properties.
Uses
Used in Pharmaceutical Industry:
L 741626 is used as a selective dopamine (D2) receptor antagonist for studying its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. This helps researchers understand the role of D2 receptors in dopamine uptake and develop potential treatments for related disorders.
Used in Neuroscience Research:
L 741626 is used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release. This application aids in understanding the interaction between dopamine receptors and other neurotransmitters, which can be crucial for developing treatments for neurological and endocrine disorders.
Hazard
A poison.
Biochem/physiol Actions
L-741,626 is a selective dopamine (D2) receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 81226-60-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,2 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 81226-60:
(7*8)+(6*1)+(5*2)+(4*2)+(3*6)+(2*6)+(1*0)=110
110 % 10 = 0
So 81226-60-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
81226-60-0Relevant articles and documents
Synthesis and characterization of selective dopamine D2 receptor antagonists
Vangveravong, Suwanna,McElveen, Elizabeth,Taylor, Michelle,Xu, Jinbin,Tu, Zhude,Luedtke, Robert R.,Mach, Robert H.
, p. 815 - 825 (2006)
A series of indole compounds have been prepared and evaluated for affinity at D2-like dopamine receptors using stably transfected HEK cells expressing human D2, D3, or D4 dopamine receptors. These compounds shar
Antipsychotic piperidinomethyl-indole derivatives
-
, (2008/06/13)
The invention relates to compounds of formula II STR1 and their pharmaceutically acceptable salts wherein R5 represents hydrogen, acyl, lower alkyl or cycloalkyl; R6 represents hydrogen, halogen, trifluormethyl, or lower alkyl; Rsup