81282-60-2

Basic information

• Product Name: 2(3H)-Benzoxazolone,7-amino-(9CI)
• Synonyms: 7-Amino-2,3-dihydro-2-oxo-1,3-benzoxazole;7-amino-3h-1,3-benzoxazol-2-one;7-Amino-2-benzoxazolinone;2(3H)-Benzoxazolone,7-amino-(9CI);7-Amino-1,3-benzoxazol-2(3H)-one;7-Amino-2-benzoxazolone;7-Aminobenzo[d]oxazol-2(3H)-one
• CAS NO: 81282-60-2
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.13
• EINECS: 462-910-8
• Product Categories: AMINEPRIMARY;Chemical Amines;Amines;Aromatics;Heterocycles
• Mol File: 81282-60-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.438 g/cm³
• Refractive Index: 1.659
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.06±0.70(Predicted)
• CAS DataBase Reference: 2(3H)-Benzoxazolone,7-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzoxazolone,7-amino-(9CI)(81282-60-2)
• EPA Substance Registry System: 2(3H)-Benzoxazolone,7-amino-(9CI)(81282-60-2)

Safety Data

• Hazardous Substances Data: 81282-60-2(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

Intermediate for the preparation of bifeprunox mesylate

InChI:InChI=1/C7H6N2O2/c8-4-2-1-3-5-6(4)11-7(10)9-5/h1-3H,8H2,(H,9,10)

Upstream product

• 26386-88-9 diphenyl phosphoryl azide 
• 603-87-2 2-amino-6-nitrophenol 
• 573-56-8 2,6-dinitrophenol 
• 6358-08-3 4-chloro-6-nitro-2-aminophenol 
• 811810-67-0 5-chloro-7-nitrobenzo[d]oxazol-2(3H)-one 
• 81117-90-0 7-nitro-3H-benzooxazol-2-one 

Downstream Products

• 1338064-72-4 1-(4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)urea 
• 1338064-73-5 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)urea 
• 1338064-74-6 1-(4-(trifluoromethyl)-2-(piperidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)urea 
• 1338064-96-2 2-(4-(trifluoromethyl)phenyl)-N-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)acetamide 
• 871367-14-5 7-bromo-1,3-benzoxazol-2(3H)-one 

Relevant articles and documents

MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS

The present invention relates to compounds compound according to Formula (III); and pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds have D2receptor antagonist/(partial) agonist effects and H3antagonistic effects, pharmaceutical compositions thereof, and methods of using them for application in the prophylaxis or treatment of CNS disorders.

"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active

POLYMORPHS OF PARDOPRUNOX

This invention relates to a process for the preparation of 7-(4-methyl-1-piperazinyl)benzoxazol-2(3H)-one hydrochloride, a partial dopamine-D2 receptor agonist and a full serotonin 5-HT1A receptor agonist. 7-(4-methyl-1-piperazinyl)benzoxazol-2(3H)-one hydrochloride The invention also relates to polymorphic forms of said compound, as well as to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, to methods for preparing intermediates useful for their synthesis, and to methods for preparing compositions containing these compounds. The invention also relates to the use of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in conditions or diseases of the central nervous system, caused by disturbances of the dopaminergic and/or serotonergic systems, for example: anxiety disorders (including generalized anxiety, panic disorder and obsessive compulsive disorder), depression, autism, schizophrenia, Parkinson's disease, restless leg syndrome, and disturbances of cognition and memory.