81304-93-0

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[2-(1-cyclohexen-1-yl)ethyl]-
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-[2-(1-cyclohexen-1-yl)ethyl]-;2-[2-(cyclohex-1-en-1-yl)ethyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 81304-93-0
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.31168
• Mol File: 81304-93-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[2-(1-cyclohexen-1-yl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[2-(1-cyclohexen-1-yl)ethyl]-(81304-93-0)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[2-(1-cyclohexen-1-yl)ethyl]-(81304-93-0)

Safety Data

• Hazardous Substances Data: 81304-93-0(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 3399-73-3 2-(1-cyclohexenyl)ethylamine 

Downstream Products

• 347380-66-9 2-(2-cyclohex-1-enyl-ethyl)-3-thioxo-2,3-dihydro-isoindol-1-one 

Relevant articles and documents

Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor α

Benzylphthalimide analogs (P1P's) and phenethylphthalimide analogs (P2P's) have been found to exhibit thalidomide-like activity on the production of tumor necrosis factor (TNF)-α by the human leukemia cell line, HL-60, stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA). Structure-activity relationships are discussed on the basis of the TNF-α production-enhancing activity. Benzylphthalimide (P1P-00) exhibited activity which is weaker than that of thalidomide, but introduction of a methyl group at the ortho-position of the benzyl moiety (P1P-10) resulted an increase to a level comparable with that of thalidomide. Phenethylphthalimide (P2P-00) is more potent than thalidomide, and its fluorinated derivative, 2-phenethyl-4,5,6,7-tetrafluoro- 1H-isoindole-1,3-dione (FP2P-00), exhibited potent activity at very low concentrations.