81316-55-4

Basic information

• Product Name: 2-<(2-chloro-3,4-dimethoxyphenyl)methyl>-5-(4-methoxyphenyl)-2-oxazoline
• Synonyms: 2-<(2-chloro-3,4-dimethoxyphenyl)methyl>-5-(4-methoxyphenyl)-2-oxazoline
• CAS NO: 81316-55-4
• Molecular Weight: 361.825
• Mol File: 81316-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-<(2-chloro-3,4-dimethoxyphenyl)methyl>-5-(4-methoxyphenyl)-2-oxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(2-chloro-3,4-dimethoxyphenyl)methyl>-5-(4-methoxyphenyl)-2-oxazoline(81316-55-4)
• EPA Substance Registry System: 2-<(2-chloro-3,4-dimethoxyphenyl)methyl>-5-(4-methoxyphenyl)-2-oxazoline(81316-55-4)

Safety Data

• Hazardous Substances Data: 81316-55-4(Hazardous Substances Data)

Upstream product

• 55275-61-1 2-amino-1-(4-methoxyphenyl)ethanol 
• 81316-63-4 ethyl (2-chloro-3,4-dimethoxyphenyl)acetimidate hydrochloride 

Downstream Products

• 71636-38-9 N-[2-hydroxy-2-(4'-methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 

Relevant articles and documents

Oxazolines. 2. 2-Substituted 2-Oxazolines as Synthons for N-(β-Hydroxyethyl)arylalkylamines, Intermediates in a Synthesis of 1,2,3,4-Tetrahydroisoquinolines and 2,3,4,5-Tetrahydro-1H-3-Benzazepines

2-(Arylalkyl)-2-oxazolines 4 (n = 1) and 2-aryl-2-oxazolines 4 (n = 0), the latter prepared in a novel reaction by cross-coupling aryl Grignard reagents with 2-(methylthio)-5-phenyl-2-oxazoline (10) and using palladium(II) chloride (14) as a catalyst, were reduced in a previously unreported reaction by diborane in refluxing THF to yield N-(β- hyroxyethyl)arylalkylamines 5 (n = 1,2).Amino alcohols 5 were cyclized to their respective heterocyclic derivatives 6 (n = 1,2) by treatment with H2SO4/TFA in refluxing methylene chloride.This paper disscuses how 2-substituted 2-oxazolines may be used to prepare1,2,3,4-tetrahydroisoquinolines 6 (n = 1) and 2,3,4,5-tetrahydro-1H-3-benzazepines 6 (n = 2) via amino alcohols 5.