81328-62-3Relevant articles and documents
Diastereoselective synthesis of (±)-trichodiene and (±)-trichodiene-D3as analytical standards for the on-site quantification of trichothecenes
Gebauer, Julian,Koch, Matthias,Sebald, Michael A.
, p. 9872 - 9879 (2021/12/07)
The ubiquitous Fusarium genus is responsible for the spoilage of vast amounts of cereals and fruits. Besides the economic damage, the danger to human and animal health by the concomitant exposure to mycotoxins represents a serious problem. A large number of Fusarium species produce a variety of different mycotoxins of which the class of trichothecenes are of particular importance due to their toxicity. Being identified as the common volatile precursor during the biosynthesis of trichothecenes, (-)-trichodiene (TD) is considered to be a biomarker for the respective mycotoxin content in food samples. We postulated that the development of a non-invasive, on-site GC-IMS method for the quantification of (-)-trichodiene supplemented with a stationary SIDA headspace GC-MS reference method would allow circumventing the laborious and expensive analyses of individual trichothecenes in large cereal samples. In this work we present the syntheses of the required native calibration standard and an isotope labeled (TD-D3) internal standard. This journal is
Formal total synthesis of (±)-trichodiene via Claisen rearrangement and Robinson annulation
Jung, Jae-Chul,Jung, Young-Jo,Park, Oee-Sook
experimental part, p. 293 - 297 (2009/01/31)
A facile formal total synthesis of (±)-trichodiene was achieved by employing Claisen rearrangement and Robinson annulation as synthetic key strategies.
(2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors
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, (2008/06/13)
Compounds of formula (i) and of formula (ii) wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate α2B and/or α2C adrenergic receptors in preference over α2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.