81329-48-8

Basic information

• Product Name: 1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazole
• Synonyms: 1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazole
• CAS NO: 81329-48-8
• Molecular Weight: 190.22
• Mol File: 81329-48-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazole(81329-48-8)
• EPA Substance Registry System: 1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazole(81329-48-8)

Safety Data

• Hazardous Substances Data: 81329-48-8(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 371-40-4 4-fluoroaniline 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 371-14-2 4-fluorophenylhydrazine 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 1765-93-1 4-fluoroboronic acid 
• 10199-63-0 1-(3,5-dimethyl-1H-pyrazol-1-yl)ethanone 
• 352-34-1 4-fluoro-1-iodobenzene 

Relevant articles and documents

Preparation method of pyrazole derivative

The present invention discloses a method for preparing a pyrazole derivative. The method comprises the following steps: the arylhydrazine derivative is mixed with an alkyldione derivative, reaction, to obtain a pyrazole derivative; wherein the structure of the arylhydrazine derivative is as follows: the structure of the alkyldione derivative is as follows: the structure of the pyrazole derivative provided by the present invention is green safe, simple and efficient, mild conditions, no catalyst, low cost, high synthesis efficiency. This method can synthesize a variety of 1,3,4,5-tetra-substituted pyrazole derivatives, and the method can be widely used in the field of organic synthesis.

Visible-light enabled C4-thiocyanation of pyrazoles by graphite-phase carbon nitride (g-C3N4)

Thiocyanation is an important and effective way to form C[sbnd]S bonds in organic synthetic methodology. Especially, thiocyanation of pyrazole attracts the attention of many researchers because sulfur-containing compounds are widely applied in many crucial fields such as organic materials, agrochemistry, nanotechnology, etc. Herein, we described A rapid metal- and additive-free method for C(sp2)-H thiocyanation of pyrazoles under visible light at room temperature by using a sustainable catalyst of graphite-phase carbon nitride (g-C3N4) and a thiocyanating agent of ammonium thiocyanate. The method presents many advantages, such as usage of eco-friendly photoredox catalyst, a wide range of substrates and a good yield of products, etc.

Oxone-DMSO Triggered Methylene Insertion and C(sp2)-C(sp3)-H-C(sp2) Bond Formation to Access Functional Bis-Heterocycles

Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)-C(sp3)-H-C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bis-pyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.