813445-25-9

Basic information

• Product Name: {(7S,8R)-7-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamic acid benzyl ester
• Synonyms: {(7S,8R)-7-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamic acid benzyl ester
• CAS NO: 813445-25-9
• Molecular Weight: 496.622
• Mol File: 813445-25-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {(7S,8R)-7-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(7S,8R)-7-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamic acid benzyl ester(813445-25-9)
• EPA Substance Registry System: {(7S,8R)-7-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamic acid benzyl ester(813445-25-9)

Safety Data

• Hazardous Substances Data: 813445-25-9(Hazardous Substances Data)

Upstream product

• 813445-24-8 ((7R,8R)-7-Formyl-1,4-dioxa-spiro[4.5]dec-8-yl)-carbamic acid benzyl ester 
• 275815-80-0 (S)-3-(4-fluorobenzyl)-piperidine 

Downstream Products

• 813445-26-0 {(1R,2S)-2-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-4-oxo-cyclohexyl}-carbamic acid benzyl ester 

Relevant articles and documents

Process of preparing N-ureidoalkyl-piperidines

The present application describes a process of preparing a compound of formula (IV), or salt or stereoisomer thereof: wherein Pg, at each occurrence, is independently selected from an amine protecting group; comprising the steps of reacting a compound of Formula with a reducing agent to give a compound of Formula III: reacting the compound of formula (III) with an amine of formula (IIa) using reductive amination to give the compound of formula (III)