813468-90-5

Basic information

• Product Name: 2-(2-((5-nitropyridin-2-yl)amino)ethyl)isoindoline-1,3-dione
• Synonyms: 2-(2-((5-nitropyridin-2-yl)amino)ethyl)isoindoline-1,3-dione
• CAS NO: 813468-90-5
• Molecular Weight: 312.285
• Mol File: 813468-90-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-((5-nitropyridin-2-yl)amino)ethyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-((5-nitropyridin-2-yl)amino)ethyl)isoindoline-1,3-dione(813468-90-5)
• EPA Substance Registry System: 2-(2-((5-nitropyridin-2-yl)amino)ethyl)isoindoline-1,3-dione(813468-90-5)

Safety Data

• Hazardous Substances Data: 813468-90-5(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 29602-39-9 2-(2-aminoethylamino)-5-nitropyridine 

Downstream Products

• 29602-39-9 2-(2-aminoethylamino)-5-nitropyridine 

Relevant articles and documents

Kinetic versus thermodynamic access to imidazoisoindolones, benzimidazoisoindolones, and [1,4]diazepinoisoindolones: Intramolecular nitrogen and π-aromatic trapping of N-acyliminium cation

Efficient assembly of substituted imidazo[2,1-a]isoindolones I is reported from suitable α,β-diamine IV (or corresponding β-nitroamine) and phthalic anhydride (1) in a three- or four-step sequence in good yields. The key step of this methodology is based on an intramolecular α-aza- amidoalkylation of the N-acyliminium species. Furthermore, when R2 is an aromatic moiety a competing α-amidoalkylation took place and imidazo[2,1-a]isoindolones (or benzimidazo[2,1-a]isoindolones) I and/or isoindolo[1,4]benzodiazepines III were obtained under kinetic or thermodynamic control. The chemoselectivity of these transformations is also discussed.