81366-75-8

Basic information

• Product Name: 9-[3-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine
• CAS NO: 81366-75-8
• Molecular Formula: C₁₈H₂₁N₅O₅
• Molecular Weight: 387.3898
• Mol File: 81366-75-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 702.1°C at 760 mmHg
• Flash Point: 378.4°C
• Density: 1.59g/cm³
• Vapor Pressure: 1.09E-20mmHg at 25°C
• Refractive Index: 1.72
• CAS DataBase Reference: 9-[3-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[3-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine(81366-75-8)
• EPA Substance Registry System: 9-[3-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine(81366-75-8)

Safety Data

• Hazardous Substances Data: 81366-75-8(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 58-61-7 adenosine 

Relevant articles and documents

COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis

(Chemical Equation Presented) Antibiotic resistance represents one of the greatest threats to public health. The adenylation inhibitor 5′-O-[N-(salicyl)sulfamoyl]adenosine (SAL-AMS) is the archetype for a new class of nucleoside antibiotics that target iron acquisition in pathogenic microorganisms and is especially effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. Strategic incorporation of fluorine at the 2′ and 3′ positions of the nucleoside was performed by direct fluorination to enhance activity and improve drug disposition properties. The resulting SAL-AMS analogues were comprehensively assessed for biochemical potency, whole-cell antitubercular activity, and in vivo pharmacokinetic parameters. Conformational analysis suggested a strong preference of fluorinated sugar rings for either a 2′-endo, 3′-exo (South), or a 3′-endo,2′-exo (North) conformation. The structure-activity relationships revealed a strong conformational bias for the C3′-endo conformation to maintain potent biochemical and whole-cell activity, whereas improved pharmacokinetic properties were associated with the C2′-endo conformation.