81397-85-5

Basic information

• Product Name: 2-(4-BROMOPHENYL)-3-HYDROXY-1H-INDEN-1-ONE
• Synonyms: 2-(4-BROMOPHENYL)-3-HYDROXY-1H-INDEN-1-ONE
• CAS NO: 81397-85-5
• Molecular Formula: C15H9BrO2
• Molecular Weight: 301.13
• Mol File: 81397-85-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 137 °C
• Boiling Point: 451°C at 760 mmHg
• Flash Point: 226.5°C
• Appearance: /
• Density: 1.657g/cm³
• Vapor Pressure: 6.39E-09mmHg at 25°C
• Refractive Index: 1.721
• CAS DataBase Reference: 2-(4-BROMOPHENYL)-3-HYDROXY-1H-INDEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOPHENYL)-3-HYDROXY-1H-INDEN-1-ONE(81397-85-5)
• EPA Substance Registry System: 2-(4-BROMOPHENYL)-3-HYDROXY-1H-INDEN-1-ONE(81397-85-5)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S36/37:Wear suitable protective clothing and gloves.
• Hazardous Substances Data: 81397-85-5(Hazardous Substances Data)

Usage

Description

2-(4-BROMOPHENYL)-3-HYDROXY-1H-INDEN-1-ONE, commonly known as Bromindione, is a chemical compound characterized by the molecular formula C14H9BrO2. It presents as a yellow to brown powder and serves as a crucial intermediate in the synthesis of pharmaceuticals and other organic compounds. Bromindione is recognized for its capacity to inhibit organic anion transporting polypeptides, which play a significant role in drug absorption and disposition within the body. Its applications extend to various fields, including medicinal chemistry, biochemistry, and pharmacology, while also showing potential as a fungicide and a reagent in organic synthesis. However, due to its potential health and environmental risks, careful handling and use are advised.

Uses

Used in Pharmaceutical Synthesis:
Bromindione is utilized as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its ability to inhibit organic anion transporting polypeptides makes it a valuable component in the creation of medications that require specific absorption and disposition profiles in the body.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Bromindione is employed for its potential to influence the transport of organic anions, which can be instrumental in the design and optimization of drug molecules with improved pharmacokinetic properties.
Used in Biochemistry:
Bromindione's role in inhibiting organic anion transporting polypeptides is also significant in biochemistry, where it can be used to study the mechanisms of drug transport and develop a deeper understanding of the processes involved in drug absorption and disposition.
Used in Pharmacology:
Pharmacologists use Bromindione to explore its effects on drug absorption and disposition, potentially leading to advancements in drug delivery systems and the optimization of drug efficacy and safety.
Used in Fungicide Development:
Bromindione has been studied for its potential as a fungicide, indicating its use in the development of antifungal agents to combat fungal infections and protect crops.
Used in Organic Synthesis Reactions:
As a reagent in organic synthesis, Bromindione is employed to facilitate various chemical reactions, contributing to the synthesis of complex organic compounds for research and industrial applications.

InChI:InChI=1/C15H9BrO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,17H