81477-94-3 Usage
Description
N-(Diphenylmethylene)glycerine tert-butyl ester is an organic compound that serves as a valuable intermediate in various chemical reactions and applications. It is characterized by its diphenylmethylene group attached to a glycerine backbone with a tert-butyl ester functional group, which contributes to its unique chemical properties and reactivity.
Uses
Used in Suzuki Reaction:
N-(Diphenylmethylene)glycerine tert-butyl ester is used as a reactant in the Suzuki reaction, a widely employed cross-coupling process in organic synthesis. This reaction allows for the formation of carbon-carbon bonds between an organoboron compound and an organic halide or triflate, facilitated by a palladium catalyst. The use of N-(Diphenylmethylene)glycerine tert-butyl ester in this reaction enables the synthesis of various complex organic molecules with potential applications in pharmaceuticals, agrochemicals, and materials science.
Used in Organic Synthesis:
N-(Diphenylmethylene)glycerine tert-butyl ester is used as an intermediate in organic synthesis for the preparation of a range of compounds. Its unique structure allows for further functionalization and modification, making it a versatile building block for the synthesis of target molecules with specific properties and applications.
Used in Pharmaceuticals:
N-(Diphenylmethylene)glycerine tert-butyl ester is used as a key intermediate in the synthesis of pharmaceutical compounds. Its reactivity and structural features make it suitable for the development of new drugs with potential therapeutic applications.
Used in Agrochemicals:
N-(Diphenylmethylene)glycerine tert-butyl ester is used as a starting material in the production of agrochemicals, such as pesticides and herbicides. Its involvement in the synthesis of these compounds contributes to the development of effective solutions for crop protection and management.
Used in Dye Industry:
N-(Diphenylmethylene)glycerine tert-butyl ester is used as a dye in the dye industry. Its unique chromophoric properties make it suitable for the development of dyes with specific color characteristics and applications in various industries, such as textiles, plastics, and printing.
Used in Biological Research:
N-(Diphenylmethylene)glycerine tert-butyl ester is used as a dye for biological research purposes. Its ability to bind and stain specific biological structures makes it a valuable tool for researchers in the study of cellular and molecular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 81477-94-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,7 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81477-94:
(7*8)+(6*1)+(5*4)+(4*7)+(3*7)+(2*9)+(1*4)=153
153 % 10 = 3
So 81477-94-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H21NO2/c1-19(2,3)22-17(21)14-20-18(15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-13H,14H2,1-3H3
81477-94-3Relevant articles and documents
Access to α,α-Disubstituted Disilylated Amino Acids and Their Use in Solid-Phase Peptide Synthesis
Fanelli, Roberto,Salah, Khoubaib Ben Haj,Inguimbert, Nicolas,Didierjean, Claude,Martinez, Jean,Cavelier, Florine
, p. 4498 - 4501 (2015)
A concise synthetic pathway yielding to hydrophobic α,α-disubstituted disilylated amino acids based on a hydrosilylation reaction is described. As a first example of utilization in solid-phase peptide synthesis, TESDpg was introduced in replacement of Aib in an alamethicin sequence, leading to analogues with modified physicochemical properties and conserved helical structures. This study highlights the potential of these new amino acids as tools for peptide modulation.
Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
Al Temimi, Abbas H. K.,White, Paul B.,Mulders, Marcus J. M.,Van Der Linden, Nicole G. A.,Blaauw, Richard H.,Wegert, Anita,Rutjes, Floris P. J. T.,Mecinovi?, Jasmin
supporting information, p. 3039 - 3042 (2020/03/18)
We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically constrained analogues containing rigid (E)-alkene (KE), (Z)-alkene (KZ) and alkyne (Kyne) moieties. Methyltransferases G9a and GLP do have a capacity to catalyse methylation in the order K ? KE > KZ ～ Kyne, whereas monomethyltransferase SETD8 catalyses only methylation of K and KE,.
Enantio- and Diastereoselective Synthesis of β-Aryl-β-pyrazolyl α-Amino Acid Esters via Copper-Catalyzed Reaction of Azomethine Ylides with Benzylidenepyrazolones
Gong, Yan-Chuan,Wang, Yue,Li, Er-Qing,Cui, Hao,Duan, Zheng
supporting information, (2019/02/07)
A fully stereoselective synthesis of unnatural chiral β-aryl-β-pyrazolyl α-amino acid esters via copper-catalyzed addition reactions of azomethine ylides with benzylidenepyrazolones bearing two contiguous stereogenic centers was developed. A 1H-pyrazol-5-ol was introduced by the aromatization of 3H-pyrazol-3-one in the reaction. The transformation operated at room temperature and afforded β-1H-pyrazol-5-ol-α-amino esters in high yields with good to excellent levels of diastereo- and enantioselectivity.
