81539-95-9

Basic information

• Product Name: Benzoic acid 2-(4-methyl-piperazin-1-yl)-ethyl ester; hydrobromide
• CAS NO: 81539-95-9
• Molecular Weight: 410.149
• Mol File: 81539-95-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid 2-(4-methyl-piperazin-1-yl)-ethyl ester; hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid 2-(4-methyl-piperazin-1-yl)-ethyl ester; hydrobromide(81539-95-9)
• EPA Substance Registry System: Benzoic acid 2-(4-methyl-piperazin-1-yl)-ethyl ester; hydrobromide(81539-95-9)

Safety Data

• Hazardous Substances Data: 81539-95-9(Hazardous Substances Data)

Upstream product

• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 93-58-3 benzoic acid methyl ester 

Relevant articles and documents

Diazabicycloalkanes with nitrogen atoms in the nodal positions. 8. Effect of c-substituents on the N-methylation of 1,4-diazabi cyclo[2.2.2]octanes and the demethylation of their bisquaternary salts

The introduction of substituents with various inductive constants in the 2 position of the diazabicyclo]2.2.2]octane ring gives rise to a change in the pKa values and affects the ease of introduction of a methyl group in the 1 and 4 positions, as well as the rate of demethylation of the bisquaternary salts from the 1 position. When 1,4-diazabicyclo[2.2.2]octane is treated with a sufficiently strong nucleophile, the ring is opened to give a piperazine derivative.