81623-63-4

Basic information

• Product Name: (2S,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione
• Synonyms: (2S,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione
• CAS NO: 81623-63-4
• Molecular Weight: 257.293
• Mol File: 81623-63-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione(81623-63-4)
• EPA Substance Registry System: (2S,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione(81623-63-4)

Safety Data

• Hazardous Substances Data: 81623-63-4(Hazardous Substances Data)

Upstream product

• 1498-64-2 O-ethyl dichlorothiophosphate 
• 40626-29-7 Acutrim 

Downstream Products

• 420087-33-8 (2R,3R)-2-methyl-3-phenylaziridine 
• 152-20-5 O,O,S-trimethyl phosphorothioate 
• 57557-26-3 R-(+)-ethyl OS-dimethyl phosphorothioate 
• 81581-19-3 O-ethyl O-methyl N-(β-hydroxy-α-methylphenethyl)-phosphoramidothioate 
• 81581-23-9 (R)-Thiophosphoric acid O-((1S,2R)-2-amino-1-phenyl-propyl) ester O'-ethyl ester O''-methyl ester 

Relevant articles and documents

1,3,2-Oxazaphospholidine-2-thiones from (+)-Norephedrine: Stereospecific Ring Opening, Possibly by an Elimination-Addition Mechanism

1,3,2-Oxazaphospholidine-2-thiones derived from (+)-norephedrine react with alkoxide to give a product of kinetic control, formed by endocyclic P-O cleavage with inversion of configuration, and one of thermodynamic control, formed by endocyclic P-N cleavage also with inversion of configuration.It is suggested that the product of kinetic control is formed by an elimination-addition process involving a metaphosphorimidate intermediate, and that of thermodynamic control by a mechanism involving nucleophilic attack opposite endocyclic nitrogen.