816446-16-9Relevant articles and documents
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors
Pajouhesh, Hassan,Feng, Zhong-Ping,Zhang, Lingyun,Pajouhesh, Hossein,Jiang, Xinpo,Hendricson, Adam,Dong, Haiheng,Tringham, Elizabeth,Ding, Yanbing,Vanderah, Todd W.,Porreca, Frank,Belardetti, Francesco,Zamponi, Gerald W.,Mitscher, Lester A.,Snutch, Terrance P.
scheme or table, p. 4153 - 4158 (2012/07/14)
We previously reported the small organic N-type calcium channel blocker NP078585 that while efficacious in animal models for pain, exhibited modest L-type calcium channel selectivity and substantial off-target inhibition against the hERG potassium channel