816456-12-9Relevant articles and documents
First synthesis of rac-(5-2H3)-α-CEHC, a labeled analogue of a major vitamin E metabolite
Mazzini, Francesco,Netscher, Thomas,Salvadori, Piero
, p. 9303 - 9306 (2004)
Over the past few years, quantitative determination of α- and γ-CEHC, main urinary metabolites of vitamin E, has been becoming more and more important as a key parameter in assessing oxidative stress and supplementation of tocopherols. The use of deuterated analogues of these metabolites allows their accurate determination even in complex matrixes. While preparation of γ-CEHC-d2 has already been described, here we report the first synthesis of α-CEHC-d3 together with α-tocopheronolactone-d3, its oxidation product.