817-95-8

Basic information

• Product Name: Ethyl ethoxyacetate
• Synonyms: TIMTEC-BB SBB007971;DIETHYL GLYCOLATE;ETHYL ETHOXYACETATE;ETHOXYACETIC ACID-ETHYL ESTER;ETHYL 2-ETHOXYACETATE;2-ETHYL ETHOXYACETATE;2-ETHOXYACETIC ACID ETHYL ESTER;Ethylethoxyacetat
• CAS NO: 817-95-8
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.16
• EINECS: 212-447-0
• Product Categories: Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks
• Mol File: 817-95-8.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 156 °C(lit.)
• Flash Point: 119 °F
• Appearance: Clear colorless/Liquid
• Density: 0.975 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.68mmHg at 25°C
• Refractive Index: n20/D 1.402(lit.)
• Storage Temp.: Flammables area
• Water Solubility: insoluble
• BRN: 1749545
• CAS DataBase Reference: Ethyl ethoxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl ethoxyacetate(817-95-8)
• EPA Substance Registry System: Ethyl ethoxyacetate(817-95-8)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 817-95-8(Hazardous Substances Data)

Usage

Description

Ethyl ethoxyacetate is an ester compound characterized by its clear colorless liquid appearance. It is known to participate in the ozonation of ethers, which is a significant chemical reaction involving the conversion of ethers into other organic compounds.

Uses

Used in Chemical Synthesis:
Ethyl ethoxyacetate is used as a chemical intermediate for the preparation of ethoxyacetylacetone. This application is crucial in the synthesis of various organic compounds and pharmaceuticals, where ethoxyacetylacetone serves as a key building block.
Used in the Preparation of Ethoxyacetylacetone:
Ethyl ethoxyacetate is utilized as a precursor in the synthesis of ethoxyacetylacetone, which is an important compound in the production of various organic and pharmaceutical products. Its role in this process highlights its value as a versatile chemical intermediate.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 260, 1943Tetrahedron, 38, p. 2733, 1982 DOI: 10.1016/0040-4020(82)80031-8

InChI:InChI=1/C6H12O3/c1-3-8-5-6(7)9-4-2/h3-5H2,1-2H3

Upstream product

• 408538-34-1 triethoxy-ethene 
• 105-36-2 ethyl bromoacetate 
• 58995-67-8 triethyl orthoethoxyacetate 
• 21969-36-8 1,2-dibromo-1,2-diethoxy-ethane 
• 57987-56-1 1,2-diethoxy-1,2-dichloro-ethane 
• 64-17-5 ethanol 
• 627-03-2 3-oxapentanoic acid 
• 62957-60-2 2-ethoxyacetonitrile 
• 620-73-5 phenyl chloroacetate 
• 141-52-6 sodium ethanolate 
• 623-73-4 diazoacetic acid ethyl ester 
• 100-42-5 styrene 
• 462-95-3 formaldehyde diethyl acetal 
• 201230-82-2 carbon monoxide 

Downstream Products

• 101168-47-2 1-ethoxy-3-[2]pyridyl-acetone 
• 5452-75-5 ethyl 2-cyclohexylacetate 
• 859077-92-2 2-ethoxy-1-cyclohexyl-ethanol 
• 859777-70-1 2-ethoxy-1,1-dicyclohexyl-ethanol 
• 74-96-4 ethyl bromide 
• 623-86-9 acetoxy-acetic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 105-36-2 ethyl bromoacetate 
• 41051-14-3 ethyl 4-ethoxy-3-oxobutanoate 
• 17718-67-1 4-(ethoxymethyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 668478-56-6 3-(4-benzyloxy-2-ethoxy-phenyl)-2(Z,E)-ethoxy-acrylic acid ethyl ester 
• 496063-08-2 ethyl [5-(benzyloxy)-2,3-dihydro-1H-inden-1-ylidene](ethoxy)ethanoate 
• 1214260-73-7 (Z)-2-ethoxy-3-(4-methoxyphenyl)propenoic acid 
• 1363293-87-1 4-ethoxy-2-(4-methylphenyl)-3-oxobutanenitrile 

Relevant articles and documents

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Three-Component Reaction for the Synthesis of Highly Functionalized Propargyl Ethers

Multicomponent reactions provide efficient means to access molecular complexity. Herein, we report a copper-catalyzed three-component reaction of diazo compounds, alcohols and ethynyl benziodoxole (EBX) reagents for the synthesis of propargyl ethers. Extensive variations of the three partners of the reaction is possible, leading to highly functionalized and structurally diverse products under mild conditions. Alkynylation of a copper ylide intermediate is postulated as key step for this transformation.

Silica-supported HClO4 promotes catalytic solvent- and metal-free O-H insertion reactions with diazo compounds

Solvent-free O-H insertion reactions in the presence of diazo carbonyl compounds were carried-out in very mild conditions. Unlike the traditional metal-catalysed version, employing rhodium acetate dimer, this method uses eco-friendly silica-supported HClO4 as the catalyst. Only 0.3 mol% of this Br?nsted acid catalyst, that can also be recycled several times, is necessary to guarantee very good yields (up to 97%) in the O-H insertion reactions. Reaction set-up is simple and permitted the preparation of forty-three α-hydroxy and α-alkoxy esters/ketones in just 1 h and at room temperature.

Acetal carbonylation product preparation method

The present invention provides a method for producing an ethylene glycol production intermediate acetal carbonylation product through an acetal carbonylation reaction, wherein the method comprises that a raw material acetal and raw material gas carbon monoxide are subjected to a carbonylation reaction with a catalyst supporting an acidic EMT and FAU eutectic structure molecular sieve through a reactor to obtain the product acetal carbonylation product. According to the present invention, the conversion rate of the raw material acetal is high, the selectivity of the acetal carbonylation product is high, the service life of the catalyst is long, the additional solvent is not required, the reaction conditions are mild, the continuous production can be achieved, the industrial application potential is provided, and ethylene glycol can be produced from the obtained acetal carbonylation product sequentially through hydrogenation and hydrolysis.