817167-04-7Relevant articles and documents
Synthesis of a Gln-Phe hydroxy-ethylene dipeptide isostere
Haug, Bengt Erik,Rich, Daniel H.
, p. 4783 - 4786 (2007/10/03)
(Chemical Equation Presented) The protected Gln-Phe hydroxyethylene dipeptide isostere 1 was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as 2 with functionalized P1 side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.