81720-37-8

Basic information

• Product Name: Benzenemethanol, 4-pentyl-
• CAS NO: 81720-37-8
• Molecular Formula: C12H18O
• Molecular Weight: 178.274
• Mol File: 81720-37-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-pentyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-pentyl-(81720-37-8)
• EPA Substance Registry System: Benzenemethanol, 4-pentyl-(81720-37-8)

Safety Data

• Hazardous Substances Data: 81720-37-8(Hazardous Substances Data)

Upstream product

• 6853-57-2 4-pentylbenzaldehyde 
• 26311-45-5 4-pentylbenzoic acid 
• 49763-65-7 4-pentylbenzoyl chloride 
• 627-19-0 1-Pentyne 
• 26311-44-4 methyl 4-pentylbenzoate 
• 1409942-09-1 methyl 4-(pent-1-yn-1-yl)benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 475208-89-0 ethyl-4-pentylbenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 1313217-06-9 tert-butyl (tert-butoxycarbonyl {6-[(4-pentylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate 
• 1313216-00-0 {6-[(4-pentylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid 
• 126156-31-8 2-Iodosyl-4-pentyl-benzoic acid 
• 950508-74-4 1-pentyl-4-(2-phenylethyl)benzene 
• 116894-07-6 p-pentylphenylacetic acid chloride 
• 14377-21-0 4-pentylphenylethanoic acid 
• 186962-87-8 2-bromo-4'-n-pentylstilbene 

Relevant articles and documents

Azole-based non-peptidomimetic plasmepsin inhibitors

The spread of drug-resistant malaria parasites urges the search for new antimalarial drugs. Malarial aspartic proteases – plasmepsins (Plms) – are differentially expressed in multiple stages of the Plasmodium parasite's lifecycle and are considered as attractive drug targets. We report the development of novel azole-based non-peptidomimetic plasmepsin inhibitors that have been designed by bioisosteric substitution of the amide moiety in the Actelion amino-piperazine inhibitors. The best triazole-based inhibitors show submicromolar potency toward Plm II, which is comparable to that of the parent Actelion compounds. The new inhibitors can be used as a starting point for the development of a resistance-free antimalarial drug targeting the non-digestive Plm IX or X, which are essential for the malaria parasite life cycle.

Making a difference on excited-state chemistry by controlling free space within a nanocapsule: Photochemistry of 1-(4-alkylphenyl)-3-phenylpropan-2-ones

The free space within a reaction cavity plays a determining role during the excited-state reaction of 1-(4-alkylphenyl)-3-phenylpropan-2-ones included within a capsule formed by two molecules of a deep cavity cavitand. By controlling the free space within the reaction cavity through remote alkyl substitution on the reactant ketone it is possible to control the yield of the rearrangement product shown above.

Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships

Sphingosine-1-phosphate (S1P) is an intracellular second messenger and an extracellular mediator through endothelial differentiation gene (EDG) receptors, which are a novel class of G-protein-coupled receptors. Although EDG has attracted much attention because of its various roles, no selective agonists or antagonists have yet been developed. This could account for the delay in clarifying the physiological roles of members of the EDG family. Because precise structural information on EDG receptors is not yet available, pharmacophore models were generated based on structural information for S1P using the rational drug design software Catalyst. Novel antagonists, 2-alkylthiazolidine-4-carboxylic acids, were retrieved from a three-dimensional database search using the pharmacophore models, and these showed activity for EDG3. On the basis of their nonphosphoric acid structure, more potent antagonists, 2-(m- or p-heptylphenyl)thiazolidine-4-carboxylic acid, were developed.