817210-65-4

Basic information

• Product Name: trans-3-(tert-butyldiphenylsilyloxy)-6-oxa-bicyclo[3.1.0]hexane
• Synonyms: trans-3-(tert-butyldiphenylsilyloxy)-6-oxa-bicyclo[3.1.0]hexane
• CAS NO: 817210-65-4
• Molecular Weight: 338.522
• Mol File: 817210-65-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: trans-3-(tert-butyldiphenylsilyloxy)-6-oxa-bicyclo[3.1.0]hexane(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3-(tert-butyldiphenylsilyloxy)-6-oxa-bicyclo[3.1.0]hexane(817210-65-4)
• EPA Substance Registry System: trans-3-(tert-butyldiphenylsilyloxy)-6-oxa-bicyclo[3.1.0]hexane(817210-65-4)

Safety Data

• Hazardous Substances Data: 817210-65-4(Hazardous Substances Data)

Upstream product

• 14320-38-8 cyclopent-3-enol 
• 182801-94-1 tert-butyl(diphenyl)silyl 3-cyclopenten-1-yl ether 

Downstream Products

• 135827-32-6 (1S,4S)-4-(tert-Butyl-diphenyl-silanyloxy)-cyclopent-2-enol 
• 865302-27-8 (1R,4S)-4-(t-butyldiphenylsilanyloxy)cyclopent-2-enol 
• 817210-69-8 C₃₂H₃₈N₂O₇SSi 
• 817210-66-5 C₃₂H₃₈N₂O₇SSi 
• 817210-73-4 [(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-carbamic acid tert-butyl ester 
• 657397-04-1 (-)-4-(N-tert-butoxycarbonylamino)cyclopentenone 
• 201054-55-9 (+)-(1R,4S)-1-hydroxy-4-[(tert-butoxycarbonyl)amino]-2-cyclopentene 

Relevant articles and documents

NOVEL CYCLOPENTANE DERIVATIVES

The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Chiral base route to functionalised cyclopentenyl amines: Formal synthesis of the cyclopentene core of nucleoside Q

A chiral base route to a range of highly functionalised amino cyclopentenes has been developed. The key asymmetric step involved the chiral lithium amide base-mediated rearrangement of a protected trans-4-hydroxy cyclopentene oxide to give an allylic alcohol (88% ee). Subsequent Overman rearrangement gave a protected trans-1,2-aminocyclopentenol whereas Mitsunobu substitution with BocNHNs gave a protected cis-amino cyclopentenol. Both are proven intermediates for natural product synthesis. The protected cis-aminocyclopentenol was transformed in a few steps into a precursor of the cyclopentene core of nucleoside Q, a natural product whose deficiency in animals is related to tumour growth.