817638-75-8Relevant articles and documents
A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes
Sivakumar, Krishnamoorthy,Xie, Fang,Cash, Brandon M.,Long, Su,Barnhill, Hannah N.,Wang, Qian
, p. 4603 - 4606 (2004)
(Chemical equation presented) Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications.