819076-59-0

Basic information

• Product Name: (R)-[1-benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 819076-59-0
• Molecular Weight: 400.493
• Mol File: 819076-59-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-[1-benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-[1-benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-carbamic acid tert-butyl ester(819076-59-0)
• EPA Substance Registry System: (R)-[1-benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-carbamic acid tert-butyl ester(819076-59-0)

Safety Data

• Hazardous Substances Data: 819076-59-0(Hazardous Substances Data)

Upstream product

• 79069-15-1 N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 2343-22-8 5-fluoroindoline 
• 79069-54-8 (S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal 

Downstream Products

• 769963-50-0 N-{(S)-1-[(R)-1-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-3-cyclohexyl-propyl}-3-methoxy-benzamide 
• 849671-62-1 (R)-1-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylamine 

Relevant articles and documents

Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.