81925-35-1

Basic information

• Product Name: 2-bromo-3,4,5-trimethoxybenzyl bromide
• Synonyms: 2-bromo-3,4,5-trimethoxybenzyl bromide
• CAS NO: 81925-35-1
• Molecular Weight: 340.011
• Mol File: 81925-35-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-bromo-3,4,5-trimethoxybenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3,4,5-trimethoxybenzyl bromide(81925-35-1)
• EPA Substance Registry System: 2-bromo-3,4,5-trimethoxybenzyl bromide(81925-35-1)

Safety Data

• Hazardous Substances Data: 81925-35-1(Hazardous Substances Data)

Upstream product

• 73252-54-7 (2-bromo-3,4,5-trimethoxyphenyl)methanol 
• 35274-53-4 2-bromo-3,4,5-tri-methoxybenzaldehyde 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 

Downstream Products

• 72326-72-8 2-bromo-3,4,5-trimethoxy-1-methylbenzene 
• 1527501-68-3 N-(2-bromo-3,4,5-trimethoxybenzyl)-4-methylbenzenesulfonamide 
• 1527501-96-7 2,3,4-trimethoxy-6-tosyl-5,6-dihydroindolo[1,2-a]quinazoline 
• 946071-56-3 2-bromo-3,4,5-trimethoxybenzylamine 
• 1094739-82-8 1-(2-bromo-3,4,5-trimethoxybenzyl)-4-nitro-1H-pyrazole-3-carbonitrile 
• 1018331-25-3 C₁₃H₁₆BrNO₅ 
• 130611-40-4 (4S,5S)-2-(4,5,6,2',3',4'-Hexamethoxy-6'-methyl-biphenyl-2-yl)-4-methoxymethyl-5-phenyl-4,5-dihydro-oxazole 
• 130611-40-4 (4S,5S)-2-(4,5,6,2',3',4'-Hexamethoxy-6'-methyl-biphenyl-2-yl)-4-methoxymethyl-5-phenyl-4,5-dihydro-oxazole 
• 187795-83-1 2-amino-5-(2'-bromo-3',4',5'-trimethoxybenzyl)-4-methylthiophene-3-carbonitrile 

Relevant articles and documents

CuI-catalyzed coupling of gem-dibromovinylanilides and sulfonamides: An efficient method for the synthesis of 2-amidoindoles and indolo[1,2-a] quinazolines

A Cu(I)-catalyzed, intermolecular protocol for the synthesis of 2-amidoindoles and tetrahydroindolo[1,2-a]quinazolines in shorter time and high yields is reported. The key highlight of this disclosure is the formation of 2-amidoindole and tetrahydroindolo[1,2-a]quinazoline moieties directly from gem-dibromovinylanilides and sulfonamides in a one-pot fashion through the in situ formation of ynamides followed by a base-promoted intramolecular hydroamidation.

Cyanocuprate-Mediated Intramolecular Biaryl Couplings Applied to an Ellagitannin. Synthesis of (+)-O-Permethyltellimagrandin II

Generation of an intramolecularly tethered, nonracemic diaryl cuprate followed by its oxidation with ground state oxygen at -78 deg leads to a biaryl precursor to an ellagitannin.Subsequent attachment of the appropriate glucose unit completes the synthesi

A SIMPLIFIED ISOQUINOLINE SYNTHESIS

A simple variation of the Pomeranz-Fritsch cyclization provides a short, efficient route to isoquinolines.Treatment of benzylic halides or mesylates 1 with the sodium anion of N-tosyl aminoacetaldehyde dimethyl acetal (2) followed by acid-catalyzed cyclization provides an effective, two-step preparation of isoquinolines 4.