82081-46-7

Basic information

• Product Name: 4-chlorobutyl 2-pyridylmethyl sulfide
• Synonyms: 4-chlorobutyl 2-pyridylmethyl sulfide
• CAS NO: 82081-46-7
• Molecular Weight: 215.747
• Mol File: 82081-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chlorobutyl 2-pyridylmethyl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorobutyl 2-pyridylmethyl sulfide(82081-46-7)
• EPA Substance Registry System: 4-chlorobutyl 2-pyridylmethyl sulfide(82081-46-7)

Safety Data

• Hazardous Substances Data: 82081-46-7(Hazardous Substances Data)

Upstream product

• 4377-33-7 2-chloromethylpyridine 

Relevant articles and documents

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.