820957-38-8 Usage
Description
Retosiban is a selective oxytocin receptor antagonist that is being developed as a potential treatment for preterm labor. It works by blocking the action of oxytocin, a hormone that can trigger uterine contractions, and has shown promise in delaying preterm labor in clinical trials.
Uses
Used in Obstetrics and Gynecology:
Retosiban is used as a potential treatment for preterm labor, helping women carry their pregnancies closer to full term and reducing the risk of complications for both the mother and the baby. It addresses a significant unmet medical need and has the potential to improve outcomes for preterm birth, which is a leading cause of infant mortality and long-term health issues. Further research and development of Retosiban could lead to a valuable new option for preventing preterm labor and its associated complications.
Check Digit Verification of cas no
The CAS Registry Mumber 820957-38-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,0,9,5 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 820957-38:
(8*8)+(7*2)+(6*0)+(5*9)+(4*5)+(3*7)+(2*3)+(1*8)=178
178 % 10 = 8
So 820957-38-8 is a valid CAS Registry Number.
820957-38-8Relevant articles and documents
The discovery of GSK221149A: A potent and selective oxytocin antagonist
Liddle, John,Allen, Michael J.,Borthwick, Alan D.,Brooks, David P.,Davies, David E.,Edwards, Richard M.,Exall, Anne M.,Hamlett, Chris,Irving, Wendy R.,Mason, Andrew M.,McCafferty, Gerald P.,Nerozzi, Fabrizio,Peace, Simon,Philp, Joanne,Pollard, Derek,Pullen, Mark A.,Shabbir, Shaila S.,Sollis, Steve L.,Westfall, Timothy D.,Woollard, Pat M.,Wu, Charlene,Hickey, Deirdre M.B.
, p. 90 - 94 (2008/09/18)
Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has been shown to inhibit oxytocin-induced uterine contractions in the anaesthetised rat.