820959-17-9

Basic information

• Product Name: N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine
• Synonyms: N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine;Acetyl tetrapeptide-5;Acetyl Tetrapeptide;Depuffin/Acetyl Tetrapeptide-5;Acetyl Tetrapeptide-5/eyeseryl;Depuffin;tetrapeptide;Eyeseryl / Acetyl Tetrapeptide-5
• CAS NO: 820959-17-9
• Molecular Formula: C20H28N8O7
• Molecular Weight: 492.49
• EINECS: 1312995-182-4
• Product Categories: BEAUTY PEPTIDES
• Mol File: 820959-17-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1237.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.443
• Storage Temp.: 2-8°C
• PKA: 2.76±0.10(Predicted)
• CAS DataBase Reference: N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine(820959-17-9)
• EPA Substance Registry System: N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine(820959-17-9)

Safety Data

• Hazardous Substances Data: 820959-17-9(Hazardous Substances Data)

Usage

Description

N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine, also known as Acetyl Tetrapeptide-5, is a synthetic peptide with a molecular weight of 492.5 and the amino acid sequence Ac-βAla-His-Ser-His-OH. It is a white to cream-colored powder that has calming, smoothing, hydrating, and firmness-enhancing benefits when applied to the skin.

Uses

Used in Cosmetics Industry:
N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine is used as a calming agent for reducing undereye puffiness due to fluid accumulation, such as from allergies. It is also used for its hydrating and firmness-enhancing properties, which help improve skin elasticity and overall smoothness.
Used in Skincare Products:
N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine is used as a humectant or hydroscopic moisturizer in skincare products to reduce eye puffiness, improve skin elasticity, and provide a smoothing effect on the skin.
Used in Anti-aging Treatments:
N-Acetyl-beta-alanyl-L-histidyl-L-seryl-L-histidine is used in anti-aging treatments to stimulate cell metabolism, improve skin elasticity, and reduce puffiness and water retention in the eye area, making the skin supple and youthful.

Characteristics

Acetyl tetrapeptide-5 inhibits collagen glycation avoiding skin losing elasticity and subsequent eyebags formation . Acetyl tetrapeptide-5 prevents liquid accumulation in eyebags . Acetyl tetrapeptide-5 shows a slight lightening effect which decreases dark circles under the eyes Use level: 0.01 %, maximum 0.1 % (water soluble)

benefits

Acetyl tetrapeptide-5 is an acetyl oligopeptide whose role is to inhibit collagen glycation and increase vascular permeability in a dose-dependent manner. This prevents liquid accumulation under the eyes and decreases eye puffiness, as well as improving skin elasticity. Two studies showed that acetyl tetrapeptide-5 reduced under-eye puffiness and discoloration.

Safety

Some humectants may be irritants at extremely high concentrations, but acetyl tetrapeptide-5 is generally considered non-hazardous to the body and the environment by the cosmetics database.