82100-78-5

Basic information

• Product Name: Thiazole, 4-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-
• CAS NO: 82100-78-5
• Molecular Formula: C14H12ClN3S
• Molecular Weight: 289.788
• Mol File: 82100-78-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Thiazole, 4-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 4-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-(82100-78-5)
• EPA Substance Registry System: Thiazole, 4-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-(82100-78-5)

Safety Data

• Hazardous Substances Data: 82100-78-5(Hazardous Substances Data)

Upstream product

• 1124-15-8 3,5-dimethyl-1H-pyrazole-1-carbothioamide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 123-54-6 acetylacetone 
• 53896-48-3 2-iodo-4'-chloroacetophenone 
• 79-19-6 thiosemicarbazide 
• 13651-12-2 2,2-dibromo-1-(4-chlorophenyl)ethanone 
• 61323-64-6 [4-(4-Chloro-phenyl)-thiazol-2-yl]-hydrazine 

Relevant articles and documents

Synthesis and antibacterial activity of some 4-(coumarin-3-yl)/Aryl 2 (3,5-dimethylpyrazol-1-yl)thiazoles

Reaction of 3-(2-bromoacetyl) coumarins (4) with 3,5-dimethylpyrazol-1- thiocarboxamide (5) results in the formation of title compounds 6. 4-Aryl-2-(3,5-dimethylpyrazol-1-yl) thiazoles (8) which could not be synthesized earlier through this method, were obtained by performing the reaction in presence of a base. All the synthesized compounds have shown moderate to significant antibacterial activity against Gram-positive bacteria namely S. aureus and B. subtilis.

A facile one-pot synthesis of 2-pyrazolyl-4-aryl-thiazoles in a threecomponent reaction

A one-pot multi-component reaction of phenacylbromide, thiosemicarbazide and acetyl acetone or ethyl acetoacetate is described for the preparation of the title compounds. The key features of this methodology are its operational simplicity, mild reaction conditions, and good yields.

Unexpected Formation of α-Thiocyanatoketones in Hantzsch Thiazole Synthesis

The reaction of 3,5-dimethylpyrazole-1-thiocarboxamide (3) with α-haloketones (4) yields the corresponding α-thiocyanatoketones (5) or pyrazoles (1) depending upon nature of the halogen.Many such pyrazole derivatives have erroneously been described as thiazolotriazepines in literature.