82159-06-6 Usage
Description
(5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID, also known as AGN-190168, is a thiazolidine-2,4-dione derivative that possesses potential anti-inflammatory and anti-fibrotic properties. This small molecule targets the enzyme PPAR-gamma to inhibit the pro-inflammatory and pro-fibrotic cytokine transforming growth factor beta (TGF-β). It has demonstrated promising results in preclinical studies for treating idiopathic pulmonary fibrosis and scleroderma, with favorable pharmacokinetic and safety profiles, making it a potential candidate for further development as a therapeutic agent for fibrotic and inflammatory conditions.
Uses
Used in Pharmaceutical Industry:
(5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID is used as a therapeutic agent for the treatment of idiopathic pulmonary fibrosis and scleroderma. Its ability to inhibit TGF-β and target PPAR-gamma makes it a promising candidate for managing these fibrotic and inflammatory conditions.
Used in Research and Development:
In the field of medical research, (5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID is used as a research compound to study its potential effects on various diseases and conditions related to inflammation and fibrosis. This can lead to the development of new treatment strategies and a better understanding of the underlying mechanisms of these conditions.
Used in Drug Development:
(5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID is utilized in the development of new drugs targeting fibrotic and inflammatory conditions. Its favorable pharmacokinetic and safety profiles make it a valuable compound for further research and potential clinical trials.
Check Digit Verification of cas no
The CAS Registry Mumber 82159-06-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,1,5 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82159-06:
(7*8)+(6*2)+(5*1)+(4*5)+(3*9)+(2*0)+(1*6)=126
126 % 10 = 6
So 82159-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO3S2/c14-10(15)7-13-11(16)9(18-12(13)17)6-8-4-2-1-3-5-8/h6,8H,1-5,7H2,(H,14,15)/p-1/b9-6-
82159-06-6Relevant articles and documents
Rhodanineacetic acid derivatives as potential drugs: Preparation, hydrophobic properties and antifungal activity of (5-arylalkylidene-4-oxo-2- thioxo-1,3-thiazolidin-3-yl)acetic acids
Dolezel, Jan,Hirsova, Petra,Opletalova, Veronika,Dohnal, Jiri,Marcela, Vejsova,Kunes, Jiri,Jampilek, Josef
experimental part, p. 4197 - 4212 (2010/03/03)
Some [(5Z)-(5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)]acetic acids were prepared as potential antifungal compounds. The general synthetic approach to all synthesized compounds is presented. Lipophilicity of all the discussed rhodanine-3-acetic acid derivatives was analyzed using a reversed phase high performance liquid chromatography (RP-HPLC) method. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using an end-capped non-polar C18 stationary RP column. The RP-HPLC retention parameter log k (the logarithm of the capacity factor k) is compared with log P values calculated in silico. All compounds were evaluated for antifungal effects against selected fungal species. Most compounds exhibited no interesting activity, and only {(5Z)-[4-oxo-5-(pyridin-2- ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]}acetic acid strongly inhibited the growth of Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/Iand Trichosporon asahii 1188.
Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient
-
, (2008/06/13)
The rhodanine derivatives of the general formula: STR1 wherein (I) R1 and R2 are taken together to represent a tetramethylene or pentamethylene group; (II) R1 represents a hydrogen atom, and R2 represents (1) a
