821785-10-8Relevant articles and documents
Stereospecific reaction of α-carbamoyloxy-2-alkenylboronates and α-carbamoyloxy-alkylboronates with grignard reagents - Synthesis of highly enantioenriched secondary alcohols
Beckmann, Edith,Desai, Vidya,Hoppe, Dieter
, p. 2275 - 2280 (2004)
Highly enantioenriched secondary alcohols were synthesized by treatment of α-carbamoyloxy-2-alkenylboronates and α-carbamoyloxy-alkylboronates with Grignard reagents. An intermediary boronate complex was transformed stereospecifically to the corresponding secondary 2-alkenyl- and alkylboronates by migration of an introduced residue. Oxidative workup furnished the enantioenriched secondary alcohols.
Bronsted acid catalyzed asymmetric reduction of ketones and acyl silanes using chiral anti -pentane-2,4-diol
Matsuo, Jun-Ichi,Hattori, Yu,Ishibashi, Hiroyuki
supporting information; experimental part, p. 2294 - 2297 (2010/08/05)
Ketones and acyl silanes were reduced to the corresponding alcohols by a simple procedure employing anti-1,3-diol and a catalytic amount (5 mol %) of 2,4-dinitrobenzenesulfonic acid in benzene at reflux. Asymmetric induction reached up to >99% ee when a chiral pentane-2,4-diol of 97% ee was used.
Design of small molecule ketoamide-based inhibitors of cathepsin K
Catalano, John G.,Deaton, David N.,Long, Stacey T.,McFadyen, Robert B.,Miller, Larry R.,Payne, J. Alan,Wells-Knecht, Kevin J.,Wright, Lois L.
, p. 719 - 722 (2007/10/03)
A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P2 and P3 elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenua
