821794-54-1 Usage
Description
MethylMalonyl DL-Carnitine Chloride (Mixture of DiastereoMers) is a metabolite of Carnitine, which is an essential amino acid that plays a crucial role in the transport of fatty acids into the mitochondria for energy production. MethylMalonyl DL-Carnitine Chloride (Mixture of DiastereoMers) is a mixture of diastereomers, which are stereoisomers that are not mirror images of each other.
Uses
Used in Diagnostic Applications:
MethylMalonyl DL-Carnitine Chloride (Mixture of DiastereoMers) is used as a diagnostic marker for the screening of patients with inherited disorders of fatty acid oxidation. This application is crucial in identifying and managing these disorders, which can lead to severe health complications if left untreated.
Used in Medical Industry:
In the medical industry, MethylMalonyl DL-Carnitine Chloride (Mixture of DiastereoMers) is used as a diagnostic tool for inherited metabolic disorders. Its ability to indicate the presence of specific disorders makes it a valuable asset in the early detection and treatment of these conditions, ultimately improving patient outcomes and quality of life.
Check Digit Verification of cas no
The CAS Registry Mumber 821794-54-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,1,7,9 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 821794-54:
(8*8)+(7*2)+(6*1)+(5*7)+(4*9)+(3*4)+(2*5)+(1*4)=181
181 % 10 = 1
So 821794-54-1 is a valid CAS Registry Number.
821794-54-1Relevant articles and documents
Kinetic and molecular orbital analyses of dicarboxylic acylcarnitine methylesterification show that derivatization may affect the screening of newborns by tandem mass spectrometry
Maeda, Yasuhiro,Nakajima, Yoko,Gotoh, Kana,Hotta, Yuji,Kataoka, Tomoya,Sugiyama, Naruji,Shirai, Naohiro,Ito, Tetsuya,Kimura, Kazunori
supporting information, p. 121 - 125 (2015/12/18)
Newborns are routinely screened for organic acidemias by acylcarnitine analysis. We previously reported the partial catalytic methylesterification of dicarboxylic acylcarnitines by benzenesulfonic acid moiety in the solid extraction cartridge during extraction from serum. Since the diagnosis of organic acidemias by tandem mass spectrometry is affected by the higher molecular weight of these derivatized acylcarnitines, we investigated the methylesterification conditions. The kinetic constants for the methylesterification of carboxyl groups on the acyl and carnitine sides of carnitine were 2.5 and 0.24 h-1, respectively. The physical basis underlying this difference in methylesterification rates was clarified theoretically, illustrating that methylesterification during extraction proceeds easily and must be prevented.
