82258-36-4 Usage
Description
Etomoxir is a chemical compound that acts as an inhibitor of carnitine palmitoyltransferase A (CPT1), an enzyme necessary for the oxidation of long-chain acyl CoA esters. It is a strong inhibitor of mitochondrial CPT1 and has potential as an anti-diabetic drug.
Uses
Used in Pharmaceutical Industry:
Etomoxir is used as an anti-diabetic drug for its ability to inhibit mitochondrial CPT1, which plays a crucial role in the regulation of fatty acid oxidation and glucose metabolism. This inhibition can help improve insulin sensitivity and reduce blood sugar levels in diabetic patients.
Used in Research Applications:
Etomoxir is used as a research tool to study the role of CPT1 in various biological processes, including fatty acid metabolism, energy production, and the development of metabolic disorders. By inhibiting CPT1, researchers can gain insights into the mechanisms underlying these processes and identify potential therapeutic targets for the treatment of related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 82258-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,5 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82258-36:
(7*8)+(6*2)+(5*2)+(4*5)+(3*8)+(2*3)+(1*6)=134
134 % 10 = 4
So 82258-36-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3
82258-36-4Relevant articles and documents
The Baylis-Hillman chemistry in aqueous media: A convenient synthesis of 2-methylenealkanoates and alkanenitriles
Basavaiah, Deevi,Kumaragurubaran, Nagaswamy
, p. 477 - 479 (2007/10/03)
A convenient, general and efficient synthesis of 2-methylenealkanoates and alkanenitriles is accomplished via the regioselective nucleophilic (SN2′) addition of hydride ion from NaBH4 to (2Z)-2-(bromomethyl)alk-2-enoates and 2-(bromomethyl)alk-2-enenitriles respectively in the presence of DABCO in environment friendly aqueous media. Synthesis of two hypoglycemic agents is also described.
Versatile synthesis of 2-aryloxyalkyl-oxirane-2-carboxylate: Syntheses of ethyl 2-[6-(3-alkoxyphenoxy)-hexyl]oxirane-2-carboxylates
Suh, Young-Ger,Min, Kyung-Hoon,Back, So-Young,Chai, Jung-Hyeon
, p. 1527 - 1535 (2007/10/03)
A versatile synthetic route to 2-aryloxyalkyl-oxirane-2-carboxylates as potential hypoglycemic agent has been developed via combination of dioxirane epoxidation of inactive olefin and facile aryl alkyl ether formation of the labile epoxy alcohol by Mitsun
Phospholipase A2 inhibitors
-
, (2008/06/13)
There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula: S
