82278-73-7 Usage
Description
(S)-N-Boc-3-Bromophenylalanine, also known as N-Boc-3-bromo-L-phenylalanine, is a chiral synthetic amino acid derivative featuring a bromo substituent at the 3-position on the phenyl ring and a Boc protecting group on the nitrogen atom. It is an off-white powder with unique chemical properties that make it a valuable building block in organic synthesis and a versatile intermediate in pharmaceutical chemistry.
Uses
Used in Pharmaceutical Industry:
(S)-N-Boc-3-Bromophenylalanine is used as a pharmaceutical intermediate for the synthesis of various bioactive compounds and drug candidates. Its unique structure allows for the development of novel therapeutic agents with potential applications in treating a wide range of diseases and medical conditions.
Used in Organic Synthesis:
(S)-N-Boc-3-Bromophenylalanine is used as a key building block in organic synthesis, enabling the creation of complex organic molecules with specific biological activities. Its bromo substituent and Boc protecting group facilitate various synthetic transformations, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
(S)-N-Boc-3-Bromophenylalanine is utilized in research and development settings to explore its potential as a precursor for the synthesis of innovative compounds with unique properties. Its chiral nature and functional groups make it an attractive target for studying the structure-activity relationships of various bioactive molecules and for developing new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 82278-73-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,7 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 82278-73:
(7*8)+(6*2)+(5*2)+(4*7)+(3*8)+(2*7)+(1*3)=147
147 % 10 = 7
So 82278-73-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H18BrNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-5-4-6-10(15)7-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/p-1/t11-/m0/s1
82278-73-7Relevant articles and documents
Preparation method of lifitegrast intermediate
-
Paragraph 0047-0048, (2020/08/09)
The invention relates to a preparation method of a lifitegrast intermediate. The preparation method is implemented by the following route, has the advantages of short synthesis route, high yield and high safety, and is simple and convenient to operate and suitable for industrial production. According to the preparation method, a compound II reacts with metal zinc in an organic solvent to generatean organic zinc reagent, a compound I carries out a coupling reaction with the organic zinc reagent, a palladium reagent and a phosphorus ligand to obtain a compound III, and Boc protecting groups ofthe compound III are removed to obtain a compound IV, wherein R1 and R2 groups are respectively and independently selected from methyl, ethyl, vinyl, n-propyl, isopropyl, propenyl, propynyl, cyclopropyl, n-butyl, isobutyl, tert-butyl, butenyl, cyclobutyl, n-pentyl, iso-pentyl, cyclopentyl, n-hexyl, cyclohexyl, phenyl and benzyl.
LFA-1 INHIBITOR AND POLYMORPH THEREOF
-
Paragraph 00120; 00121; 00122; 00123; 00124; 00125, (2014/02/16)
Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.
MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE
-
Page/Page column 56, (2009/10/09)
The invention provides compounds inhibitory to the Hepatitis C viral protease, compositions and combinations including the compounds, methods of treatment of conditions wherein inhibition of the Hepatitis C viral protease is medically indicated, and metho
