82318-20-5Relevant articles and documents
10-Propargylaminopterin and Alkyl Homologues of Methotrexate as Inhibitors of Folate Metabolism
Piper, J. R.,McCaleb, G. S.,Montgomery, J. A.,Kisliuk, R. L.,Gaumont, Y.,Sirotnak, F. M.
, p. 877 - 880 (2007/10/02)
Reported antifolate activity against leukemia L1210 by N-propargylamino>benzoyl>-L-glutamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a