82337-46-0 Usage
Description
12(R)-HETE, also known as Hydroxyeicosatetraenoic acid, is a type of eicosanoid derived from arachidonic acid through the action of lipoxygenase enzymes. It possesses a (12R)-hydroxy group and a combination of (5Z)-, (8Z)-, (10E)-, and (14Z)-double bonds, which contribute to its unique biological properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
12(R)-HETE is used as a pharmaceutical agent for its potential role in modulating inflammatory responses and other biological processes. Its specific structure allows it to interact with cellular receptors and signaling pathways, making it a promising candidate for the development of new drugs targeting various diseases.
Used in Research Applications:
In the field of scientific research, 12(R)-HETE is used as a biochemical marker for studying the role of eicosanoids in various physiological and pathological conditions. Its presence can help researchers understand the underlying mechanisms of inflammation, pain, and other related processes, ultimately contributing to the advancement of medical knowledge.
Used in Drug Development:
12(R)-HETE is utilized in drug development as a lead compound for the synthesis of new therapeutic agents. Its unique chemical structure provides a foundation for the design and optimization of novel drugs with improved efficacy, selectivity, and safety profiles, addressing unmet medical needs in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 82337-46-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,3,3 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82337-46:
(7*8)+(6*2)+(5*3)+(4*3)+(3*7)+(2*4)+(1*6)=130
130 % 10 = 0
So 82337-46-0 is a valid CAS Registry Number.
82337-46-0Relevant articles and documents
12-LIPOXYGENASE ACTIVITY IN THE RED MARINE ALGA GRACILARIOPSIS LEMANEIFORMIS
Moghaddam, Mehran Fallah,Gerwick, William H.
, p. 2457 - 2459 (1990)
The temperate red alga Gracilariopsis lemaneiformis is a rich source of polyunsaturated fatty acids that are regio-specifically oxidized at C-12.In this in vitro study, we demonstrate the existence of a highly active lipoxygenase-type activity in Gracilariopsis.GC-MS of the methyl ester, trimethylsilyl ether derivatives of the crude reaction mixture identified the production of 12-hydroxyicosatetraenoic acid, a 12-lipoxygenase product previously isolated from this alga.This is the first report of 12-lipoxygenase-type activity from the plant kingdom.
Physcomitrella patens has lipoxygenases for both eicosanoid and octadecanoid pathways
Anterola, Aldwin,G?bel, Cornelia,Hornung, Ellen,Sellhorn, George,Feussner, Ivo,Grimes, Howard
experimental part, p. 40 - 52 (2009/07/11)
Mosses have substantial amounts of long chain C20 polyunsaturated fatty acids, such as arachidonic and eicosapentaenoic acid, in addition to the shorter chain C18 α-linolenic and linoleic acids, which are typical substrates of lipoxygenases in flowering p
A short catalytic enantioselective synthesis of the proinflammatory eicosanoid 12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid (12(R)-HETE)
Han, Xiaojun,Corey
, p. 2543 - 2544 (2007/10/03)
(equation presented) A new and effective pathway is described for the synthesis of 12(R)-HETE and the 12(S)-enantiomer from the common intermediates 4 and 8.
