82341-13-7Relevant articles and documents
Nonsteroidal Antiinflammatory Agents. 1. 10,11-Dihydro-11-oxodibenzoxepinacetic Acids and Related Compounds
Nagai, Yasutaka,Irie, Akira,Nakamura, Hideo,Hino, Katsuhiko,Uno, Hitoshi,Nishimura, Haruki
, p. 1065 - 1070 (2007/10/02)
10,11-Dihydro-11-oxodibenzoxepinacetic acids and related compounds were synthesized as potential antiinflammatory agents.Among them, 2-(8-methyl-10,11-dihydro-11-oxodibenzoxepin-2-yl)propionic acid (16b) and its thiepin analogue (16c) showed excellent antipyretic activity together with potent antiinflammatory and analgesic properties in biological tests.Structure-activity relationships are discussed.