82362-17-2 Usage
Description
[5-Methionine]Enkephalin, also known as Enkephalin M or [Met5] Enkephalin (ME), is an opioid pentapeptide that functions as a neurotransmitter or neuromodulator in the central nervous system. It is derived from the precursor peptide pro-methionine-enkephalin and consists of the amino acid sequence H-Tyr-Gly-Gly-Phe-Met-Arg-OH. [5-Methionine]Enkephalin interacts with three main subtypes of receptors, including μ and δ opioid receptors for classic opioid effects, and ζ receptors for non-opioid actions such as retardation of cell growth. Its activity is observed in the central nervous, neuroendocrine, and immune systems.
Uses
Used in Pharmaceutical Research:
[5-Methionine]Enkephalin, Enkephalin M is used as a research compound for studying the effects of mutations in the opioid growth factor receptor on the growth of human cancer cell lines. This helps in understanding the role of opioid peptides in cancer cell growth and potential therapeutic applications.
Used in Neuroscience Research:
[5-Methionine]Enkephalin, Enkephalin M is used as a research tool in neuroscience to investigate the interactions of opioid peptides with μ, δ, and ζ receptors, as well as their effects on neurotransmission, neuromodulation, and cell growth regulation in the central nervous system.
Used in Immunology Research:
[5-Methionine]Enkephalin, Enkephalin M is used as an immunological agent to study its role in the immune system and its potential applications in modulating immune responses and treating immune-related disorders.
Biochem/physiol Actions
Met-enkephalin is endogenous opioid neurotransmitter/neuromodulator with agonist activity at μ and δ opioid receptors. Enhancement of immune system function is mediated through met-enkephalin receptors on leukocytes. Met-enkephalin also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 82362-17-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,3,6 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 82362-17:
(7*8)+(6*2)+(5*3)+(4*6)+(3*2)+(2*1)+(1*7)=122
122 % 10 = 2
So 82362-17-2 is a valid CAS Registry Number.