82379-38-2

Basic information

• Product Name: 4-HYDROXYMETHYL-3-NITROBENZOIC ACID
• Synonyms: 4-HYDROXYMETHYL-3-NITROBENZOIC ACID
• CAS NO: 82379-38-2
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• Product Categories: pharmacetical
• Mol File: 82379-38-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 412.9 °C at 760 mmHg
• Flash Point: 186.8 °C
• Appearance: /
• Density: 1.544 g/cm³
• Vapor Pressure: 1.47E-07mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.46±0.10(Predicted)
• CAS DataBase Reference: 4-HYDROXYMETHYL-3-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYMETHYL-3-NITROBENZOIC ACID(82379-38-2)
• EPA Substance Registry System: 4-HYDROXYMETHYL-3-NITROBENZOIC ACID(82379-38-2)

Safety Data

• Hazardous Substances Data: 82379-38-2(Hazardous Substances Data)

Usage

General Description

4-HYDROXYMETHYL-3-NITROBENZOIC ACID, also known as p-hydroxymethyl-3-nitrobenzoic acid, is a chemical compound that belongs to the class of nitrobenzoic acids. It is commonly used in the synthesis of pharmaceuticals and fine chemicals due to its versatile chemical properties. 4-HYDROXYMETHYL-3-NITROBENZOIC ACID is a nitroaromatic compound, meaning it contains a nitro group (-NO2) and an aromatic ring. It is also a derivative of benzoic acid, with a hydroxymethyl group (-CH2OH) attached to the para position of the benzene ring. 4-HYDROXYMETHYL-3-NITROBENZOIC ACID has potential applications in the formulation of drugs, agrochemicals, and other industrial chemicals due to its unique structural features and reactivity.

InChI:InChI=1/C8H7NO5/c10-4-6-2-1-5(8(11)12)3-7(6)9(13)14/h1-3,10H,4H2,(H,11,12)

Upstream product

• 6232-88-8 4-bromomethylbenzoic Acid 
• 89950-93-6 methyl 4-(hydroxymethyl)-3-nitrobenzoate 
• 55715-03-2 4-bromomethyl-3-nitrobenzoic acid 

Downstream Products

• 89950-93-6 methyl 4-(hydroxymethyl)-3-nitrobenzoate 
• 1413644-98-0 C₄₄H₆₃N₅O₁₃ 
• 508234-89-7 C₅₁H₇₅N₁₂O₁₈P 
• 508234-76-2 [4-(4-{(2-Cyano-ethoxy)-[(3aR,4R,6R,6aR)-6-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-phosphoryloxymethyl}-3-nitro-benzoylamino)-butyl]-carbamic acid tert-butyl ester 
• 508234-75-1 (4-{4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxymethyl]-3-nitro-benzoylamino}-butyl)-carbamic acid tert-butyl ester 
• 623902-44-3 3-amino-4-trityloxymethyl-benzoic acid 
• 870074-59-2 undec-10-enoic acid 4-(6-tert-butoxycarbonylamino-hexylcarbamoyl)-2-nitro-benzyl ester 
• 666848-42-6 3-nitro-4-trityloxymethyl-benzoic acid 
• 130581-93-0 4-(Hydroxymethyl)-3-nitrobenzoic acid 2,4,5-trichlorophenyl ester 
• 217461-50-2 4-Methoxy-benzoic acid 4-({butyl-[(E)-2-(toluene-4-sulfonyl)-vinyl]-amino}-methyl)-3-iodo-benzyl ester 

Relevant articles and documents

Dual system for the central nervous system targeting and blood-brain barrier transport of a selective prolyl oligopeptidase inhibitor

Less than 2% of all potential neurotherapeutics cross the blood-brain barrier (BBB). Here, we sought to build a construct with the capacity to cross this barrier, to behave as a chemical delivery system, and, once inside the central nervous system, to be

Dual Stimuli-Responsive Block Copolymers with Adjacent Redox- And Photo-Cleavable Linkages for Smart Drug Delivery

A novel dual-stimuli cleavable linker containing adjacent UV light-sensitive o-nitrobenzyl ester and GSH-responsive disulfide bonds was first designed and synthesized to increase the responsivity to external stimuli. The functionalized linker was then uti

Photo-Cleavable Surfactants

The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-trans-modifications. In addition, the present photo-cleavable anionic surfactants are also suitable for dissolving polypeptides in bottom-up proteomic experiments including extracellular matrix proteomics, and are suitable as a substitute for SDS in gel electrophoresis.

Photo-induced multifunctional cross-linking agent, preparation method and application thereof

The invention relates to a photo-induced multifunctional cross-linking agent as shown in a general formula (I), wherein the photo-induced multifunctional cross-linking agent is mainly applied to biomacromolecule interaction, such as protein-protein interaction and protein-nucleic acid interaction. According to the invention, the cross-linking agent can be used in biological samples or cells of cell lysis solutions to capture protein-protein interaction or protein-nucleic acid interaction, and can be applied to subsequent protein enrichment and protein cross-linking mass spectrometry; and the photo-induced multifunctional cross-linking agent has important application potential and practical value in interaction research of biomacromolecules.

Multi-stimuli controlled release of a transmembrane chloride ion carrier from a sulfonium-linked procarrier

In recent times, anion transporters have received substantial consideration due to their ability to disrupt the ionic equilibrium across membrane bilayers. While numerous Cl- ion transporters were developed for channelopathies, unfortunately, poor aqueous solubility precluded their bioapplicability. Herein, we demonstrate the development of a multi-stimuli activatable anion transport approach to induce regulated transport of Cl- ions across membranes under specific conditions. The sulfonium-based procarrier was initially inactive, but the transmembrane transport of Cl- ions was activated in the presence of stimuli such as glutathione (GSH), reactive oxygen species (ROS) and light. The release of the hydrophobic anionophore from the aqueous-soluble procarrier under specific conditions leads to the successful transport of Cl- ions. Under physiological conditions, these anion carriers follow an antiport exchange mechanism to transport Cl- ions across lipid bilayers. Such multi-stimuli activatable procarriers have great potential to combat various types of channelopathies, including cancer, cystic fibrosis, kidney stones, myotonia, and others.