824-54-4 Usage
Description
2-Bromo-4-methylbenzaldehyde is an organic compound that serves as a valuable intermediate in various organic synthesis processes. It is characterized by the presence of a bromine atom and a methyl group attached to a benzene ring, with an aldehyde functional group.
Uses
Used in Organic Synthesis:
2-Bromo-4-methylbenzaldehyde is used as a key intermediate for the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a versatile building block in the creation of complex molecules.
Used in Carbonylative Stille Couplings:
In the field of organic chemistry, 2-Bromo-4-methylbenzaldehyde is used as a reactant in carbonylative Stille couplings. This reaction is followed by isomerization and intramolecular Heck reactions, which are crucial for the formation of specific organic compounds.
Used in Knoevenagel Condensation:
2-Bromo-4-methylbenzaldehyde is also utilized in Knoevenagel condensation, a reaction that involves the condensation of an aldehyde or ketone with a compound containing an active methylene group, such as an ester or nitrile.
Used in Cyclization of N-(α-methyl-p-methoxybenzyl)-imino-esters:
This intermediate is employed in the cyclization of N-(α-methyl-p-methoxybenzyl)-imino-esters, a process that leads to the formation of cyclic compounds with potential applications in various industries.
Used in Imination and Oxidative Heterocyclization / Carbonylation:
2-Bromo-4-methylbenzaldehyde is involved in imination and oxidative heterocyclization or carbonylation reactions. These processes are essential for the synthesis of nitrogen-containing heterocyclic compounds, which have a wide range of applications in pharmaceuticals, agrochemicals, and materials science.
Used in Intramolecular Amination:
This intermediate is used in intramolecular amination reactions, where an amine group is introduced into a molecule through a cyclization process, leading to the formation of nitrogen-containing rings.
Used in Intermolecular and Intramolecular Hydroacylation of Alkenes:
2-Bromo-4-methylbenzaldehyde is employed in intermolecular and intramolecular hydroacylation of alkenes by aromatic aldehydes. This reaction is an important method for the synthesis of various organic compounds, including those with potential applications in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 824-54-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 824-54:
(5*8)+(4*2)+(3*4)+(2*5)+(1*4)=74
74 % 10 = 4
So 824-54-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H7BrO/c1-6-2-3-7(5-10)8(9)4-6/h2-5H,1H3
824-54-4Relevant articles and documents
Enantioselective Lewis Acid Catalyzed ortho Photocycloaddition of Olefins to Phenanthrene-9-carboxaldehydes
Stegbauer, Simone,Jandl, Christian,Bach, Thorsten
, p. 14593 - 14596 (2018/10/15)
Visible-light irradiation (λ=457 nm) enabled the enantioselective ortho photocycloaddition of olefins to phenanthrene-9-carboxaldehydes (15 examples, 46–93 % yield, 82–98 % ee). A chiral oxazaborolidine Lewis acid (20 mol %) was employed as the catalyst. It operates by coordination to the aldehyde inducing a bathochromic absorption shift beyond the nπ* absorption of the uncomplexed aldehyde. At long wavelengths the Lewis acid complex is exclusively excited; within the complex, one enantiotopic face of the aromatic aldehyde is efficiently shielded. Lewis acid coordination also alters the type selectivity and the simple diastereoselectivity of the photocycloaddition.
Synthesis of smart bimetallic nano-Cu/Ag@SiO2 for clean oxidation of alcohols
Saha, Arijit,Payra, Soumen,Banerjee, Subhash
supporting information, p. 13377 - 13381 (2017/11/27)
Here, we have demonstrated the synthesis and characterization of silica supported bimetallic copper/silver nanoparticles (Cu/Ag@SiO2 NPs) and their application in the clean oxidation of benzoins/benzyl alcohols in the presence of tert-butyl hydroperoxide as a mild oxidant. All the reactions were very fast (4 h) and high yielding (95-99%), and the Cu/Ag@SiO2 NPs were very stable under the reaction conditions. The catalyst was recovered simply by filtration and reused eight times without loss of its catalytic performance.
LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME
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Page/Page column 3-4, (2012/02/01)
There is provided a novel loxoprofen derivative that has no side effect such as a gastrointestinal disorder and also has excellent anti-inflammatory and analgesic effects and is represented by the following formula (I) or (II): (wherein R1 and
