824-98-6 Usage
Description
3-Methoxybenzyl chloride, also known as m-anisyl chloride, is an organic compound with the chemical formula C8H9ClO2. It is a clear colorless to light yellow liquid that is soluble in organic solvents. It is an aromatic compound with a methoxy group attached to the benzene ring and a chlorine atom attached to the benzyl group. This unique structure makes it a versatile reagent in organic synthesis.
Uses
Used in Pharmaceutical Industry:
3-Methoxybenzyl chloride is used as a reagent for the synthesis of various pharmaceutical compounds. It is used in the alkylation of 8-benzyloxy-2(1H)-quinolinone in the presence of DMF and NaH, which is an important intermediate in the synthesis of certain drugs.
Used in Chemical Synthesis:
3-Methoxybenzyl chloride is used as a building block in the synthesis of various organic compounds. It is used in the synthesis of diarylmethanes via in situ organozinc-mediated, palladium-catalyzed cross-coupling between benzyl and aryl halide. This method allows for the formation of carbon-carbon bonds, which are essential in the synthesis of complex organic molecules.
Used in Organic Synthesis:
3-Methoxybenzyl chloride is used as a protecting group in organic synthesis. The methoxy group can be selectively removed under mild conditions, allowing for the controlled deprotection of the benzyl group. This makes it a useful reagent in the synthesis of complex organic molecules, where selective protection and deprotection of functional groups are necessary.
Check Digit Verification of cas no
The CAS Registry Mumber 824-98-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 824-98:
(5*8)+(4*2)+(3*4)+(2*9)+(1*8)=86
86 % 10 = 6
So 824-98-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClO/c1-10-8-4-2-3-7(5-8)6-9/h2-5H,6H2,1H3
824-98-6Relevant articles and documents
Total synthesis of enhygrolide A and analogs
Guilloteau, Vincent,Petrignet, Julien,Romdhani-Younes, Moufida,Sghairi, Douha,Thibonnet, Jér?me
supporting information, (2020/03/10)
The total synthesis of enhygrolide A, a γ-alkylidene butenolide natural product which exhibits antibacterial activities, is reported. The synthetic route features several key transformations, including a copper mediated Sonogashira/oxacyclization 5-exo-dig process to generate the alkylidene butenolide system and a Suzuki cross-coupling to introduce the benzylic unit. The methodology employed for this total synthesis represents a sufficiently flexible route to allow the synthesis of numerous analogs of these enhygrolides.
Ionic-Liquid-Supported 1,3-Dimethylimidazolidin-2-one: Application as a Reusable Halogenation Reagent
Koguchi, Shinichi,Shibuya, Yuga,Igarashi, Yusuke,Takemura, Haruka
supporting information, p. 943 - 946 (2019/05/10)
We describe the synthesis of ionic-liquid-supported 1,3-dimethylimidazolidin-2-one, together with the halogenation of alcohols in a reaction system in which this reagent is combined with oxalyl chloride. A new method was established that does not require additives such as bases, and which permits the ready isolation and purification of the product. Good conversions were obtained, and good reusability of the reagent was observed.
2-OXO-3,4-DIHYDROPYRIDINE-5-CARBOXYLATES AND THEIR USE
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Page/Page column 126-127, (2016/04/20)
The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
