82420-34-6Relevant articles and documents
Synthesis of mono-functionalized S-diazocines via intramolecular Baeyer-Mills reactions
Schehr, Miriam,Hugenbusch, Daniel,Moje, Tobias,N?ther, Christian,Herges, Rainer
supporting information, p. 2799 - 2804 (2018/11/21)
Herein we report a reliable method to synthesize mono-functionalized S-diazocines in reproducible yields via intramolecular Baeyer-Mills reactions. Diazocines exhibit excellent photoswitchable properties. As opposed to azobenzenes they are more stable in
METHOD FOR PRODUCING 2-FLUORO-4-BORONO-L-PHENYLALANINE, AND A DERIVATIVE OF 2-FLUORO-4-BORONO-L-PHENYLALANINE
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Paragraph 0162; 0175, (2016/10/09)
The present invention provides a method for producing 2-fluoro-4-borono-L-phenylalanine, and aderivative of 2-fluoro-4-borono-L-phenylalanine. The invention is to prepare and use a compound represented by the following formula. In the formula, R1/su
Design, synthesis, and pharmacological evaluation of fused β-homophenylalanine derivatives as potent DPP-4 inhibitors
Jiang, Tao,Zhou, Yuren,Chen, Zhuxi,Sun, Peng,Zhu, Jianming,Zhang, Qiang,Wang, Zhen,Shao, Qiang,Jiang, Xiangrui,Li, Bo,Chen, Kaixian,Jiang, Hualiang,Wang, Heyao,Zhu, Weiliang,Shen, Jingshan
supporting information, p. 602 - 606 (2015/05/27)
Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused β-homophenylalanine derivatives as novel DPP-4 inhibitors were designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4.