824389-35-7Relevant articles and documents
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists
Jaeschke, Georg,Porter, Richard,Buettelmann, Bernd,Ceccarelli, Simona M.,Guba, Wolfgang,Kuhn, Bernd,Kolczewski, Sabine,Huwyler, Joerg,Mutel, Vincent,Peters, Jens-Uwe,Ballard, Theresa,Prinssen, Eric,Vieira, Eric,Wichmann, Juergen,Spooren, Will
, p. 1307 - 1311 (2007)
Optimization of affinity and microsomal stability led to identification of the potent, metabolically stable fenobam analog 4l. Robust in vivo efficacy of 4l was demonstrated in four different models of anxiety. Additionally, a ligand based pharmacophore a
Double elimination protocol for the synthesis of arylene ethynylenes containing heteroaromatic rings
Orita, Akihiro,Ye, Fangguo,Babu, Govindarajulu,Ikemoto, Tomohiro,Otera, Junzo
, p. 716 - 727 (2007/10/03)
The double elimination reaction of β-substituted sulfones offers a versatile strategy for synthesis of arylene ethynylene kits containing heteroaromatic rings. A sequence of aldol reaction between α-sulfonyl carbanion and aldehyde, trapping the resulting aldolate to give β-substituted sulfone, and double elimination of this intermediate can be integrated in one pot. This protocol allows thiophene, pyridine, and ferrocene units to be accommodated in phenylene ethynylene arrays.
