82475-74-9 Usage
General Description
Trimethylsilyl bis(2-chloroethyl)carbamate is a chemical compound that is used as an intermediate in the synthesis of various pharmaceuticals. It is a carbamate derivative with two 2-chloroethyl groups attached to the nitrogen atom, and trimethylsilyl groups attached to the carbamate oxygen. trimethylsilyl bis(2-chloroethyl)carbamate is commonly used in the production of pesticides, herbicides, and antineoplastic agents. It is also utilized in the synthesis of chemotherapeutic drugs and other pharmaceuticals due to its ability to act as an alkylating agent, a type of compound that can interfere with the reproduction of cancerous cells. However, it is important to handle this chemical with caution as it is toxic and potentially hazardous to human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 82475-74-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,4,7 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82475-74:
(7*8)+(6*2)+(5*4)+(4*7)+(3*5)+(2*7)+(1*4)=149
149 % 10 = 9
So 82475-74-9 is a valid CAS Registry Number.
82475-74-9Relevant articles and documents
Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs
Chiu,Chang,Ozkan,Zon,Fichter,Phillips
, p. 542 - 551 (2007/10/02)
N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.
