82477-67-6

Basic information

• Product Name: 3-CHLORO-5-METHOXY-BENZOIC ACID
• Synonyms: 3-CHLORO-5-METHOXY-BENZOIC ACID;3-Carboxy-5-chloroanisole, 5-Chloro-m-anisic acid;Benzoicacid,3-chloro-5-Methoxy;3-Chloro-5-methoxybenzoic acid 97%;3-Chloro-5-methoxy-benzoic acid≥ 97% (GC)
• CAS NO: 82477-67-6
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• Product Categories: Carboxylic Acids;Phenyls & Phenyl-Het;C8;Carbonyl Compounds
• Mol File: 82477-67-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 172-176 °C
• Boiling Point: 323.134 °C at 760 mmHg
• Flash Point: 149.227 °C
• Appearance: /
• Density: 1.353 g/cm³
• Vapor Pressure: 205.2084
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• PKA: 3.71±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-5-METHOXY-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-5-METHOXY-BENZOIC ACID(82477-67-6)
• EPA Substance Registry System: 3-CHLORO-5-METHOXY-BENZOIC ACID(82477-67-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 82477-67-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

3-chloro-5-methoxybenzoic acid

InChI:InChI=1/C8H7ClO3/c1-12-7-3-5(8(10)11)2-6(9)4-7/h2-4H,1H3,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 13362-34-0 3-methyl-1,4-benzoquinone 4-oxime 
• 124-38-9 carbon dioxide 
• 33719-74-3 3,5-dichloroanisole 
• 51-36-5 3,5-dichlorobenzoic acid 
• 124-41-4 sodium methylate 

Downstream Products

• 96826-41-4 methyl 3-chloro-5-methoxybenzoate 
• 1286232-01-6 phenyl 3-(3-chloro-5-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxylate 
• 1286232-00-5 phenyl 3-(3-chloro-5-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazole-2-carboxylate 
• 1286232-07-2 3-(3-chloro-5-methoxyphenyl)-N-(2-(dimethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-09-4 3-(3-chloro-5-methoxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-11-8 3-(3-chloro-5-methoxyphenyl)-N-(2-morpholinoethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-13-0 3-(3-chloro-5-methoxyphenyl)-N-(2-(2,6-dimethylmorpholino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-15-2 3-(3-chloro-5-methoxyphenyl)-N-(2-(4-methylpiperazin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-17-4 N-(2-(4-acetylpiperazin-1-yl)ethyl)-3-(3-chloro-5-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-18-5 3-(3-chloro-5-methoxyphenyl)-N-(2-(piperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-19-6 3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-21-0 3-(3-chloro-5-methoxyphenyl)-4-(pyridin-4-yl)-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazole-1-carboxamide 
• 1286232-22-1 3-(3-chloro-5-hydroxyphenyl)-N-(2-(dimethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 
• 1286232-24-3 3-(3-chloro-5-hydroxyphenyl)-N-(2-(diethylamino)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide 

Relevant articles and documents

Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages

Abstract: The inhibition of nitric oxide and prostaglandin E2 productions is a very interesting research topic in the field of anti-inflammatory drug development. In the current study, a new series of 1,3,4-triarylpyrazole derivatives was synth

Synthesis, in vitro antiproliferative activity, and kinase inhibitory effects of pyrazole-containing diarylureas and diarylamides

Twenty pyrazole-containing diarylureas and diarylamides were designed and synthesized. They were tested for in vitro antiproliferative activity over a 58-cancer cell line panel at the NCI, USA. The diarylurea derivatives 1b-e and 1g exerted the strongest

Synthesis of 1H-Pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of 1H-pyrazole-1-carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N-methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line.