82484-59-1

Basic information

• Product Name: Benzenamine, N,N-bis(2-chloroethyl)-4-isocyanato-
• CAS NO: 82484-59-1
• Molecular Formula: C11H12Cl2N2O
• Molecular Weight: 259.135
• Mol File: 82484-59-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenamine, N,N-bis(2-chloroethyl)-4-isocyanato-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N,N-bis(2-chloroethyl)-4-isocyanato-(82484-59-1)
• EPA Substance Registry System: Benzenamine, N,N-bis(2-chloroethyl)-4-isocyanato-(82484-59-1)

Safety Data

• Hazardous Substances Data: 82484-59-1(Hazardous Substances Data)

Upstream product

• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 55743-71-0 bis(2-chloroethyl)(4-nitrophenyl)amine 
• 2067-58-5 4-amino-N,N-bis(2-chloroethyl)aniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 503-38-8 trichloromethyl chloroformate 
• 806608-18-4 4--phenyl-carbamoylchlorid 
• 945-68-6 4-aniline dihydrochloride 
• 945-68-6 N,N-bis(2-chloroethyl)benzene-1,4-diamine hydrochloride 

Downstream Products

• 102446-42-4 N,N'-Bis-(4--phenyl)-harnstoff 
• 1036724-73-8 1-[3-(Acridin-9-ylamino)-5-methylphenyl]-3-{4-[bis(2-chloroethyl)-amino]phenyl}-urea 
• 1038623-53-8 1-[3-((2-(dimethylamino)ethyl)carbamoyl)phenyl]-3-[4-(bis(2-chloroethyl)amino)-phenyl]urea hydrochloride 
• 1036724-75-0 9-[5-(3-{4-[bis(2-chloroethyl)amino]phenyl}ureido)-2-methylphenylamino]-5-methylacridine-4-carboxylic acid (2-dimethylaminoethyl)amide 
• 1027937-67-2 C₃₂H₃₁Cl₂N₅O 
• 1038622-96-6 (3-(acridin-9-ylamino)-5-{4-[bis(2-chloroethyl)amino]phenylcarbamoyloxymethyl}phenyl)carbamic acid ethyl ester 
• 1038623-44-7 N-{4-[bis(2-chloroethyl)amino]phenyl}-2-(2-methyl-4-quinolinyl)hydrazinecarboxamide 
• 1038623-45-8 N-{4-[bis(2-chloroethyl)amino]phenyl}-2-(6-methoxy-2-methyl-4-quinolinyl)hydrazinecarboxamide 
• 1038623-47-0 N-{4-[bis(2-chloroethyl)amino]phenyl}-N'-{4-[(6-methyl[1,3]dioxolo[4,5-g]quinolin-8-yl)oxy]phenyl}urea 
• 1036724-76-1 C₃₁H₂₉Cl₂N₅O₂ 
• 1036724-78-3 C₃₁H₂₉Cl₂N₅O₂ 
• 1036724-81-8 C₃₁H₂₉Cl₂N₅O₂ 
• 1036724-82-9 C₃₂H₃₁Cl₂N₅O₂ 
• 1036724-77-2 C₃₂H₃₁Cl₂N₅O₂ 

Relevant articles and documents

Design and synthesis of potent antitumor water-soluble phenyl N-mustard-benzenealkylamide conjugates via a bioisostere approach

A series of new, water-soluble phenyl N-mustard-benzenealkylamide conjugates containing hydrophilic ω-dialkylaminoalkylamide or ω-cyclic aminoalkylamide moieties were synthesized via a bioisostere approach. These compounds have a broad spectrum of antitumor activity against a panel of human tumor cell lines. Of these derivatives, compound 18b effectively suppressed the growth of colon cancer (HCT-116), prostate cancer (PC3), and lung cancer (H460) xenografts. The growth of HCT-116 xenografts was almost completely suppressed when co-treated with compound 18b and 5-fluorouracil. Furthermore, compound 18b can induce DNA cross-linking and cell-cycle arrest at the G2/M phase. Early preclinical studies, including pharmacokinetics in rats, inhibition of the hERG, and 14 days of acute intravenous injection toxicity, suggest that compound 18b is a promising candidate for further preclinical studies.

Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents

A series of novel water-soluble N-mustard-benzene conjugates bearing a urea linker were synthesized. The benzene moiety contains various hydrophilic side chains are linked to the meta- or para-position of the urea linker via a carboxamide or an ether link

Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker

A series of N-mustard-quinoline conjugates bearing a urea or hydrazinecarboxamide linker was synthesized for antitumor evaluation. The in vitro cytotoxicity studies revealed that compounds with hydrazinecarboxamide linkers were generally more cytotoxic th