824938-65-0Relevant articles and documents
Pd0-catalyzed intramolecular α-arylation of sulfones: Domino reactions in the synthesis of functionalized tetrahydroisoquinolines
Solé, Daniel,Pérez-Janer, Ferran,Mancuso, Raffaella
supporting information, p. 4580 - 4584 (2015/03/18)
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0-catalyzed intramolecular a-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.