82510-98-3

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)BENZAL CHLORIDE
• Synonyms: 4-(TRIFLUOROMETHYL)BENZAL CHLORIDE;4-(DICHLOROMETHYL)BENZOTRIFLUORIDE;P-TRIFLUOROMETHYLBENZAL CHLORIDE;PTF-BAC;4-(Trifluoromethyl)benzal chloride 97%;4-(Trifluoromethyl)benzalchloride97%;4-(Dichloromethyl)-benzotr;3-TRIFLUOROMETHYLBENZOTRIFLUORIDE
• CAS NO: 82510-98-3
• Molecular Formula: C₈H₅Cl₂F₃
• Molecular Weight: 229.03
• Mol File: 82510-98-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: -3
• Boiling Point: 76/8mm
• Appearance: /
• Density: 1.4
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)BENZAL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)BENZAL CHLORIDE(82510-98-3)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)BENZAL CHLORIDE(82510-98-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 82510-98-3(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)benzal chloride is a chemical compound with the formula C7H4ClF3. It is a colorless liquid that is used as a precursor in the synthesis of various pharmaceuticals, agrochemicals, and dyes. The trifluoromethyl group in the compound makes it particularly useful in organic synthesis as it can be easily substituted to create a wide range of functionalized compounds. Additionally, the benzal chloride moiety in the molecule has been studied for its potential antimicrobial and antifungal properties, making this compound a versatile building block in the field of medicinal chemistry and materials science. However, it is important to handle this compound with caution due to its potential hazards and reactivity.

Upstream product

• 106-42-3 para-xylene 
• 7456-32-8 1-dichloromethyl-4-trichloromethylbenzene 
• 189096-91-1 {[4-(trifluoromethyl)phenyl]methylidene}hydrazine 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 13947-96-1 1-trichloromethyl-4-(trifluoromethyl)-benzene 

Downstream Products

• 96395-05-0 anti-9-<1-(p-trifluoromethyl)phenyl>-cis-bicyclo<6.1.0>nona-2,4,6-triene 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 1489331-57-8 C₁₈H₂₅F₃N₂O₂Te₂ 
• 13947-96-1 1-trichloromethyl-4-(trifluoromethyl)-benzene 

Relevant articles and documents

Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides

Herein, a novel method for the transformation of aldehydes into geminal dichlorides based on phthaloyl chloride as reagent and N -formylpyrrolidine as Lewis base catalyst is disclosed. Given the mild reaction conditions, the current protocol is distinguished by high levels of functional group compatibility and scalability and is operationally simple. The in situ formation of a Vilsmeier Haack reagent type intermediate is likely to be essential for this organocatalytic nucleophilic substitution reaction.

Synthesis of Aryldihalomethanes by Denitrogenative Dihalogenation of Benzaldehyde Hydrazones

We report a denitrogenative dihalogenation reaction of phenyldiazomethanes in which the hypervalent iodine reagents PhICl2 and TolIF2 act as surrogates for elemental chlorine and fluorine. Halogen transfer from iodane to aryldiazomethane is described, as is a tandem oxidative dihalogenation reaction between iodane and hydrazone. This is the first use of non-α-stabilized diazo compounds in this reaction, which provided an efficient synthesis of aryldifluoromethane (ArCHF2) and aryldichloromethane (ArCHCl2) derivatives. (Figure presented.).

REDUKTION VON BENZOTRICHLORIDEN ZU BENZALCHLORIDEN

Benzal chlorides are prepared from the corresponding benzotrichlorides by reduction with thiophenol in the presence of catalytic amounts of copper(I) bromide.